Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13573992 | 0.85 | KDM4E (0.47) | KDM4ESLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL29391452 | 0.79 | MAOA (0.40) | KDM4ESIGMAR1SMN1; SMN2 | |
| SCHEMBL24253346 | 0.79 | KDM4E (0.34) | KDM4ESLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24253343 | 0.79 | BACE1 (0.36) | KDM4EALDH1A1 | |
| SCHEMBL5986119 | 0.77 | SLC6A2 (0.41) | KDM4ESLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL22993438 | 0.76 | SLC6A2 (0.40) | KDM4ESLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL24124011 | 0.73 | KDM4E (0.48) | KDM4ESLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL22993440 | 0.73 | KDM4E (0.31) | KDM4E | |
| SCHEMBL2835665 | 0.69 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3CYP2D6ALDH1A1 | |
| SCHEMBL20180574 | 0.69 | KCNH2 (0.36) | KDM4ESIGMAR1ALDH1A1DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |