Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FASN | P49327 | 7/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | FPR3 | P25089 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14152219 | 1.00 | EPHX2 (0.41) | EPHX2THRBPOLBKMT2AFASN | |
| SCHEMBL14152164 | 0.91 | EPHX2 (0.40) | EPHX2THRBKMT2AFASNGAA | |
| SCHEMBL14152019 | 0.91 | EPHX2 (0.40) | EPHX2THRBFASNGAAPARP1 | |
| SCHEMBL14152248 | 0.84 | EPHX2 (0.39) | EPHX2THRBFASNGAAPARP1 | |
| SCHEMBL14152172 | 0.84 | EPHX2 (0.43) | EPHX2THRBFASNGAAFPR2 | |
| SCHEMBL14152226 | 0.80 | EPHX2 (0.40) | EPHX2THRBFASNGAAFPR2 | |
| SCHEMBL2298365 | 0.80 | THRB (0.44) | EPHX2THRBPOLBKMT2AGAA | |
| SCHEMBL2303512 | 0.79 | HTT (0.47) | EPHX2KMT2A | |
| SCHEMBL14151936 | 0.79 | HTT (0.47) | EPHX2KMT2A | |
| SCHEMBL14151661 | 0.79 | ALDH1A1 (0.42) | EPHX2THRBPOLBKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2538787-A1 | TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011103546-A1 | TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-08-25 | — | — | WO | disclosed |