Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 10/20 | 0.41 |
| ▸ | CCNH | P51946 | 10/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 10/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 16/20 | 0.40 |
| ▸ | CDK2 | P24941 | 16/20 | 0.40 |
| ▸ | CDK1 | P06493 | 11/20 | 0.40 |
| ▸ | CDK4 | P11802 | 11/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 11/20 | 0.40 |
| ▸ | CCND1 | P24385 | 11/20 | 0.40 |
| ▸ | CCND3 | P30281 | 11/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 11/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.40 |
| ▸ | CDK9 | P50750 | 10/20 | 0.40 |
| ▸ | CCNK | O75909 | 4/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22997813 | 0.86 | CDK7 (0.53) | CDK7CCNHMNAT1CCNE1CDK2 | |
| SCHEMBL22977299 | 0.85 | CCNE1 (0.57) | CDK7CCNHMNAT1CCNE1CDK2 | |
| SCHEMBL22977228 | 0.83 | CCNE1 (0.58) | CDK7CCNHMNAT1CCNE1CDK2 | |
| SCHEMBL22997848 | 0.79 | CDK7 (0.43) | CDK7CCNHMNAT1CCNE1CDK2 | |
| SCHEMBL22997803 | 0.77 | CCNE1 (0.42) | CDK7CCNHMNAT1CCNE1CDK2 | |
| SCHEMBL22977177 | 0.75 | CDK2 (0.57) | CDK7CCNHMNAT1CCNE1CDK2 | |
| SCHEMBL29821379 | 0.75 | CDK2 (0.57) | CDK7CCNHMNAT1CCNE1CDK2 | |
| SCHEMBL23001267 | 0.73 | CCNE1 (0.45) | CDK7CCNHMNAT1CCNE1CDK2 | |
| SCHEMBL22997705 | 0.73 | CCNE1 (0.43) | CDK7CCNHMNAT1CCNE1CDK2 | |
| SCHEMBL22976919 | 0.73 | CCNE1 (0.58) | CDK7CCNHMNAT1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021030537-A1 | IMIDAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION (US) | 2021-02-18 | — | — | WO | disclosed |