Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 18/20 | 0.42 |
| ▸ | CDK2 | P24941 | 18/20 | 0.42 |
| ▸ | CDK1 | P06493 | 14/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 14/20 | 0.42 |
| ▸ | CCND1 | P24385 | 13/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 13/20 | 0.42 |
| ▸ | CDK4 | P11802 | 12/20 | 0.42 |
| ▸ | CCND3 | P30281 | 12/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.42 |
| ▸ | CDK7 | P50613 | 6/20 | 0.42 |
| ▸ | CDK9 | P50750 | 6/20 | 0.42 |
| ▸ | CCNH | P51946 | 6/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.42 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22997813 | 0.77 | CDK7 (0.53) | CCNE1CDK2CDK1CCNB1CCND1 | |
| SCHEMBL30449148 | 0.77 | CCNE1 (0.67) | CCNE1CDK2CDK1CCNB1CCND1 | |
| SCHEMBL22900798 | 0.77 | CCNE1 (0.67) | CCNE1CDK2CDK1CCNB1CCND1 | |
| SCHEMBL22997699 | 0.77 | CDK7 (0.41) | CCNE1CDK2CDK1CCNB1CCND1 | |
| SCHEMBL23001264 | 0.74 | ULK1 (0.49) | CCNE1CDK2CDK1CCNB1CCND1 | |
| SCHEMBL11907283 | 0.72 | ULK1 (0.71) | CCNE1CDK2CCNT1CDK7CDK9 | |
| SCHEMBL26045352 | 0.72 | ULK1 (0.67) | CCNE1CDK2CDK1CCNB1CCND1 | |
| SCHEMBL22901105 | 0.72 | CCNE1 (0.65) | CCNE1CDK2CDK1CCNB1CCND1 | |
| SCHEMBL29631651 | 0.72 | CCNE1 (0.65) | CCNE1CDK2CDK1CCNB1CCND1 | |
| SCHEMBL18765976 | 0.72 | MAPK1 (0.57) | CCNE1CDK2CDK1CCNB1ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021030537-A1 | IMIDAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION (US) | 2021-02-18 | — | — | WO | disclosed |