Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.47 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.45 |
| ▸ | NOS1 | P29475 | 2/20 | 0.45 |
| ▸ | NOS2 | P35228 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31330409 | 0.86 | LRRK2 (0.51) | PRMT5WDR77PRKD1PRKD2PIP5K1C | |
| SCHEMBL828268 | 0.78 | ALDH1A1 (0.71) | NOS3NOS1NOS2KDM4EALDH1A1 | |
| SCHEMBL24473804 | 0.76 | HCAR3 (0.61) | PRMT5NOS3NOS1NOS2KDM4E | |
| SCHEMBL20449771 | 0.75 | MAPK1 (0.53) | PRKD1PRKD2CDK2NOS1NOS2 | |
| SCHEMBL15229217 | 0.75 | MAPK10 (0.50) | PRKD1PRKD2KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL29487164 | 0.75 | MAPK10 (0.50) | PRKD1PRKD2KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL21297272 | 0.74 | MAPK14 (0.52) | PRKD1PRKD2CDK2KDM4EALDH1A1 | |
| SCHEMBL18466034 | 0.74 | MAPK1 (0.51) | PRKD1PRKD2PIP5K1CKDM4EALDH1A1 | |
| SCHEMBL17072681 | 0.74 | KDM4E (0.47) | NOS3NOS1NOS2KDM4EALDH1A1 | |
| SCHEMBL1579180 | 0.74 | KDM4E (0.47) | PRKD1PRKD2PIP5K1CKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011100769-A2 | KINASE MODULATORS FOR THE TREATMENT OF CANCER | SYNOVO GMBH (DE) | 2011-08-18 | — | — | WO | disclosed |