SCHEMBL23001097

SCHEMBL23001097

CCCCCCCCCCCCCCCCCCOc1c(C)cc([N+](=O)[O-])cc1O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 2/20 0.44
THRA P10827 1/20 0.44
THRB P10828 1/20 0.44
CYP19A1 P11511 4/20 0.43
ALDH1A1 P00352 1/20 0.42
GPR35 Q9HC97 1/20 0.42
CYSLTR2 Q9NS75 1/20 0.40
CYSLTR1 Q9Y271 1/20 0.40
S1PR2 O95136 1/20 0.40
S1PR1 P21453 1/20 0.40
S1PR3 Q99500 1/20 0.40
LPAR2 Q9HBW0 1/20 0.40
KDM4E B2RXH2 1/20 0.39
TP53 P04637 1/20 0.39
MAPT P10636 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CACNA1F O60840 1/20 0.39
CACNA1D Q01668 1/20 0.39
CACNA1S Q13698 1/20 0.39
CACNA1C Q13936 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11511728 0.84 ALDH1A1 (0.46) ESR1THRATHRBCYP19A1ALDH1A1
SCHEMBL28786634 0.80 CYP19A1 (0.40) ESR1THRATHRBCYP19A1ALDH1A1
SCHEMBL462104 0.78 CYP19A1 (0.56) ESR1THRATHRBCYP19A1ALDH1A1
SCHEMBL461143 0.78 CYP19A1 (0.56) ESR1THRATHRBCYP19A1ALDH1A1
SCHEMBL17208973 0.77 GRIN2D (0.49) ESR1THRATHRBCYP19A1CYSLTR2
SCHEMBL9699858 0.76 CYP19A1 (0.58) THRATHRBCYP19A1ALDH1A1CYSLTR2
SCHEMBL27719953 0.76 CYP19A1 (0.58) THRATHRBCYP19A1ALDH1A1CYSLTR2
SCHEMBL23499773 0.76 ALDH1A1 (0.51) ALDH1A1GPR35KDM4EMAPTL3MBTL1
SCHEMBL17817211 0.75 ESR1 (0.56) ESR1THRATHRBALDH1A1GPR35
SCHEMBL22342651 0.74 CYP19A1 (0.60) ESR1THRATHRBCYP19A1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3229811-B1 PREVENTION AND TREATMENT OF INFLAMMATORY CONDITIONS GRI BIO INC (US) 2021-02-24 EP disclosed