Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Azetidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azetidine SCHEMBL30499018 | 1.00 | FFAR3 (0.54) | — | |
| Pyrrolidine SCHEMBL2797002 | 0.93 | — | — | |
| Acetic Acid SCHEMBL9430014 | 0.93 | SMN1; SMN2 (0.50) | — | |
| Acetic Acid SCHEMBL11222550 | 0.90 | SMN1; SMN2 (0.56) | — | |
| Piperidine SCHEMBL29043025 | 0.90 | ALDH1A1 (0.56) | — | |
| Acetic Acid SCHEMBL23292732 | 0.90 | SMN1; SMN2 (0.56) | — | |
| Acetic Acid SCHEMBL3790763 | 0.90 | SMN1; SMN2 (0.56) | — | |
| Piperidine SCHEMBL10332243 | 0.90 | ALDH1A1 (0.56) | — | |
| Piperidine SCHEMBL192668 | 0.90 | ALDH1A1 (0.56) | — | |
| Acetic Acid SCHEMBL29130314 | 0.90 | SMN1; SMN2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103797011-A | Compounds and compositions as c-Kit kinase inhibitors | IRM LLC | 2014-05-14 | — | — | CN | claimed |
| CN-102256977-A | Purine compounds | LILLY CO ELI | 2011-11-23 | — | — | CN | claimed |
| CN-110520422-B | Novel pyridonecarboxylic acid derivative or salt thereof | 涌永制药株式会社 | 2023-09-05 | — | — | CN | disclosed |
| US-9340529-B2 | Triazolones as fatty acid synthase inhibitors | GLAXOSMITHKLINE LLC (US) | 2016-05-17 | — | — | US | disclosed |
| CN-103797011-B | As compound and the composition of c-Kit kinase inhibitor | NOVARTIS AG (CH) | 2016-03-30 | — | — | CN | disclosed |
| US-8802864-B2 | Triazolones as fatty acid synthase inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-08-12 | — | — | US | disclosed |
| CN-103797011-A | Compounds and compositions as c-Kit kinase inhibitors | IRM LLC | 2014-05-14 | — | — | CN | disclosed |
| CN-103764653-A | Compounds and compositions as c-Kit kinase inhibitors | IRM LLC | 2014-04-30 | — | — | CN | disclosed |
| US-20140100213-A1 | TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-04-10 | — | — | US | disclosed |
| EP-2538787-A1 | TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2013-01-02 | — | — | EP | disclosed |
| CN-102858175-A | Triazolones as fatty acid synthase inhibitors | GLAXOSMITHKLINE LLC | 2013-01-02 | — | — | CN | disclosed |
| CN-102256977-A | Purine compounds | LILLY CO ELI | 2011-11-23 | — | — | CN | disclosed |
| WO-2011103546-A1 | TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-08-25 | — | — | WO | disclosed |
| CN-1930173-A | Process for preparing cephalosporin intermediates using alpha-iodo-1-azetidineacetic acid esters and trialkylphosphites | PFIZER PROD INC (US) | 2007-03-14 | — | — | CN | disclosed |
| CN-1037177-C | Noel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them | AMERICAN CYANAMID CO (US) | 1998-01-28 | — | — | CN | disclosed |
| CN-1034332-C | Process for preparing 2-substituted alkyl-3-carboxy carbapenems as antibiotics | AMERICAN CYANAMID CO (US) | 1997-03-26 | — | — | CN | disclosed |
| CN-1034329-C | Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them | AMERICAN CYANAMID CO (US) | 1997-03-26 | — | — | CN | disclosed |
| CN-1108648-A | Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them | AMERICAN CYANAMID CO (US) | 1995-09-20 | — | — | CN | disclosed |
| CN-1056878-A | 2-substituted alkyl-3-carboxycarbapenems as antibiotics and process for their preparation | AMERICAN CYANAMID CO (US) | 1991-12-11 | — | — | CN | disclosed |
| US-3962276-A | ENZYME INHIBITORS | ELI LILLY AND COMPANY (US) | 1976-06-08 | — | — | US | disclosed |