Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 8/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.53 |
| ▸ | HTR3B | O95264 | 4/20 | 0.53 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.53 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8274290 | 0.82 | HTR3A (0.62) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL18765491 | 0.79 | HTR3A (0.58) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL18793654 | 0.79 | HTR3A (0.58) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL24925881 | 0.79 | HTR3A (0.61) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL18270122 | 0.74 | HTR3A (0.50) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL18765485 | 0.74 | HTR3E (0.46) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL29675364 | 0.74 | HTR3E (0.46) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL14618026 | 0.72 | HTR3A (0.62) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL29675627 | 0.71 | ACACB (0.50) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL29676235 | 0.71 | ACACB (0.50) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021030556-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-02-18 | — | — | WO | disclosed |