SCHEMBL23008014

SCHEMBL23008014

Cc1cccc(-c2nc(-n3ccc4c(F)nccc43)c3nc[nH]c3n2)n1

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TGFBR1 P36897 20/20 0.38
TGFBR2 P37173 10/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23007882 0.90 TGFBR1 (0.39) TGFBR1TGFBR2
SCHEMBL29366025 0.90 TGFBR1 (0.39) TGFBR1TGFBR2
SCHEMBL23007698 0.88 TGFBR1 (0.37) TGFBR1TGFBR2
SCHEMBL29363043 0.88 TGFBR1 (0.38) TGFBR1TGFBR2
SCHEMBL29365626 0.88 TGFBR1 (0.38) TGFBR1TGFBR2
SCHEMBL23007806 0.88 TGFBR1 (0.38) TGFBR1TGFBR2
SCHEMBL23008013 0.88 TGFBR1 (0.38) TGFBR1TGFBR2
SCHEMBL23007809 0.88 TGFBR1 (0.38) TGFBR1TGFBR2
SCHEMBL23007697 0.87 TGFBR1 (0.37) TGFBR1TGFBR2
SCHEMBL23007684 0.87 TGFBR1 (0.38) TGFBR1TGFBR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021027594-A1 IMIDAZOLOPYRIMIDINE COMPOUNDS COMPRISING FUSED RING GROUP, PREPARATION METHOD THEREFOR AND USE THEREOF 四川科伦博泰生物医药股份有限公司 2021-02-18 WO disclosed