Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR1E | P28566 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12802432 | 0.80 | TLR8 (0.40) | TLR8HTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL23653456 | 0.80 | GABRA1 (0.37) | HTR1AADRA2ADRD2ADRA2BADRA2C | |
| SCHEMBL19658157 | 0.78 | TLR8 (0.42) | TLR8USP2ALDH1A1HPGDTDP1 | |
| SCHEMBL12802144 | 0.76 | TAAR1 (0.53) | TLR8HTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL2970934 | 0.75 | TAAR1 (0.41) | TLR8HTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL8985363 | 0.75 | TAAR1 (0.52) | TLR8HTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL2984041 | 0.74 | SRC (0.51) | TLR8HTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL23008754 | 0.73 | TYR (0.38) | TLR8SLC6A4OPRK1SIGMAR1TDP1 | |
| SCHEMBL23008840 | 0.73 | TLR8 (0.35) | TLR8HTR6USP2ALDH1A1HPGD | |
| SCHEMBL23008863 | 0.73 | TYR (0.37) | HTR1AADRA2ADRD2ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021029632-A1 | FUSED RING HETEROARYL COMPOUNDS AS RIPK1 INHIBITORS | BISICHEM CO., LTD. (KR) | 2021-02-18 | — | — | WO | disclosed |