Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19658157 | 0.77 | TLR8 (0.42) | TP53MAPTTSHRTDP1TLR8 | |
| SCHEMBL23009103 | 0.73 | TLR8 (0.36) | TDP1TLR8SLC6A4SIGMAR1OPRK1 | |
| SCHEMBL4508414 | 0.73 | TLR8 (0.39) | TYRMEN1TP53CYP3A4ALOX5 | |
| SCHEMBL23008915 | 0.70 | TLR8 (0.34) | TLR8 | |
| SCHEMBL23008840 | 0.69 | TLR8 (0.35) | TDP1TLR8 | |
| SCHEMBL2296133 | 0.68 | CYP3A4 (0.38) | TYRMEN1TP53CYP3A4ALOX5 | |
| SCHEMBL3263073 | 0.67 | GABRA1 (0.32) | ESR1GABRA1GABRB2 | |
| SCHEMBL3263070 | 0.67 | GABRA1 (0.32) | ESR1GABRA1GABRB2 | |
| SCHEMBL109815 | 0.66 | ESR1 (0.54) | TP53CYP3A4ALOX15KMT2ATDP1 | |
| SCHEMBL12523490 | 0.66 | MEN1 (0.35) | TYRMEN1MAPTALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021029632-A1 | FUSED RING HETEROARYL COMPOUNDS AS RIPK1 INHIBITORS | BISICHEM CO., LTD. (KR) | 2021-02-18 | — | — | WO | disclosed |