SCHEMBL23009196

SCHEMBL23009196

COC(=O)/C=C\[C@H](N)COCc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC1A1 P43005 1/20 0.48
HTT P42858 1/20 0.45
CTSL P07711 2/20 0.44
MAPT P10636 1/20 0.44
TACR1 P25103 2/20 0.43
FOLH1 Q04609 1/20 0.43
PPARA Q07869 1/20 0.43
MAP3K7 O43318 1/20 0.41
TAB1 Q15750 1/20 0.41
MME P08473 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
HCAR2 Q8TDS4 1/20 0.41
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL25295973 0.99 SLC1A1 (0.47) SLC1A1HTTCTSLMAPTTACR1
Hydrochloric Acid SCHEMBL29659070 0.99 SLC1A1 (0.47) SLC1A1HTTCTSLMAPTTACR1
Hydrochloric Acid SCHEMBL25295972 0.99 SLC1A1 (0.47) SLC1A1HTTCTSLMAPTTACR1
SCHEMBL147688 0.84 CTSL (0.46) SLC1A1HTTCTSLMAPTFOLH1
SCHEMBL122159 0.84 CTSL (0.46) SLC1A1HTTCTSLMAPTFOLH1
Hydrochloric Acid SCHEMBL22980618 0.84 SLC1A1 (0.51) SLC1A1HTTMAPTTACR1FOLH1
Hydrochloric Acid SCHEMBL22980621 0.84 SLC1A1 (0.51) SLC1A1HTTMAPTTACR1FOLH1
SCHEMBL10217512 0.80 CTSL (0.51) HTTCTSLKMT2A
SCHEMBL5368800 0.78 LTA4H (0.60) PPARA
SCHEMBL5368797 0.78 LTA4H (0.60) PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4010329-B9 DEUTERATED COMPOUNDS FOR USE IN THE TREATMENT OF CANCER ARTIOS PHARMA LTD (GB) 2023-10-04 EP disclosed
WO-2023125918-A1 DNA POLYMERASE THETA INHIBITOR AND USE THEREOF 上海湃隆生物科技有限公司 2023-07-06 WO disclosed
EP-4010329-B1 DEUTERATED COMPOUNDS FOR USE IN THE TREATMENT OF CANCER ARTIOS PHARMA LTD (GB) 2023-06-07 EP disclosed
WO-2021028670-A1 DEUTERATED COMPOUNDS FOR USE IN THE TREATMENT OF CANCER ARTIOS PHARMA LIMITED (GB) 2021-02-18 WO disclosed