Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.62 |
| ▸ | CASP1 | P29466 | 6/20 | 0.62 |
| ▸ | CASP7 | P55210 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3324841 | 0.89 | ALDH1A1 (0.79) | ALDH1A1MAPK1KDM4ECASP1CASP7 | |
| SCHEMBL3330293 | 0.89 | KDM4E (0.63) | ALDH1A1MAPK1TDP1KDM4ECASP1 | |
| SCHEMBL3326941 | 0.88 | KDM4E (0.77) | ALDH1A1MAPK1KDM4ECASP1CASP7 | |
| SCHEMBL3325251 | 0.88 | ALDH1A1 (0.70) | ALDH1A1MAPK1KDM4ECASP1CASP7 | |
| SCHEMBL3327812 | 0.85 | MAPK1 (0.70) | ALDH1A1MAPK1TDP1KDM4ECASP1 | |
| SCHEMBL3325121 | 0.83 | POLB (0.54) | ALDH1A1MAPK1TDP1KDM4ECASP1 | |
| SCHEMBL3320737 | 0.83 | ALDH1A1 (0.65) | ALDH1A1MAPK1KDM4ECASP1CASP7 | |
| SCHEMBL3325157 | 0.82 | KDM4E (0.70) | ALDH1A1MAPK1KDM4ECASP1CASP7 | |
| SCHEMBL3325232 | 0.82 | KDM4E (0.59) | ALDH1A1MAPK1TDP1KDM4ECASP1 | |
| SCHEMBL3325228 | 0.81 | ALDH1A1 (0.81) | ALDH1A1MAPK1KDM4ECASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210047278-A1 | E3 UBIQUITIN LIGASE AGONISTS, PHARMACEUTICAL COMPOSITIONS INCLUDING THE E3 UBIQUITIN LIGASE AGONISTS, RELATED METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210047278-A1 | E3 UBIQUITIN LIGASE AGONISTS, PHARMACEUTICAL COMPOSITIONS INCLUDING THE E3 UBIQUITIN LIGASE AGONISTS, RELATED METHODS OF USE | UBE3A, NEDD4, ADRM1 | ALDH1A1 1174/4885MAPK1 4812/4885TDP1 2435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.