Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.62 |
| ▸ | FPR2 | P25090 | 2/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 6/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2299212 | 0.84 | SLC6A2 (0.45) | SLC6A4SLC6A3SLC6A2FPR2PROKR1 | |
| SCHEMBL2300752 | 0.84 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2FPR2PROKR1 | |
| SCHEMBL2297195 | 0.84 | SLC6A4 (0.45) | SLC6A4SLC6A3SLC6A2KCNH2TSHR | |
| SCHEMBL3113548 | 0.81 | SLC6A4 (0.59) | SLC6A4SLC6A3SLC6A2FPR2PROKR1 | |
| SCHEMBL2297229 | 0.80 | PGR (0.54) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL2302743 | 0.78 | SLC6A4 (0.52) | SLC6A4SLC6A3SLC6A2FPR2PROKR1 | |
| SCHEMBL2301845 | 0.77 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2KCNH2 | |
| Hydrochloric Acid SCHEMBL5218770 | 0.76 | SLC6A4 (0.96) | SLC6A4SLC6A3SLC6A2KCNH2 | |
| Hydrochloric Acid SCHEMBL30357916 | 0.76 | SLC6A4 (0.96) | SLC6A4SLC6A3SLC6A2KCNH2 | |
| SCHEMBL2298742 | 0.76 | SLC6A4 (0.57) | SLC6A4SLC6A3SLC6A2FPR2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |