Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 4/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3120594 | 0.81 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3FPR2PROKR1 | |
| SCHEMBL3123523 | 0.81 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3FPR2PROKR1 | |
| SCHEMBL3115435 | 0.79 | SLC6A4 (0.53) | SLC6A4SLC6A2SLC6A3MAOAMAOB | |
| SCHEMBL2299147 | 0.78 | CA1 (0.48) | MAOAMAOBMEN1KMT2ANPC1 | |
| SCHEMBL3125920 | 0.78 | ACHE (0.41) | MEN1KMT2AMAPTFPR2PROKR1 | |
| SCHEMBL2302199 | 0.78 | EPHX2 (0.41) | MEN1KMT2AFPR2PROKR1EPHX2 | |
| SCHEMBL2301374 | 0.78 | SLC6A4 (0.37) | SLC6A4SLC6A2SLC6A3MAPTLMNA | |
| SCHEMBL2298535 | 0.78 | KMT2A (0.40) | MEN1KMT2ARAB9A | |
| SCHEMBL2300977 | 0.78 | SLC6A4 (0.62) | SLC6A4SLC6A2SLC6A3MEN1KMT2A | |
| SCHEMBL2297195 | 0.77 | SLC6A4 (0.45) | SLC6A4SLC6A2SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |