Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23010371 | 0.73 | RAPGEF4 (0.34) | HDAC1HDAC6 | |
| SCHEMBL30668 | 0.71 | HDAC1 (0.48) | NFE2L2HDAC1HDAC6 | |
| SCHEMBL23010362 | 0.69 | — | — | |
| SCHEMBL20084813 | 0.68 | CCR1 (0.32) | — | |
| SCHEMBL21572413 | 0.68 | CCR1 (0.32) | — | |
| Nitrogen SCHEMBL10699058 | 0.66 | HDAC1 (0.44) | NFE2L2HDAC1HDAC6 | |
| SCHEMBL764794 | 0.66 | RAPGEF4 (0.37) | NFE2L2HDAC1HDAC6 | |
| SCHEMBL4137547 | 0.65 | RAPGEF4 (0.32) | — | |
| SCHEMBL18680691 | 0.65 | CA3 (0.39) | NFE2L2 | |
| SCHEMBL1056730 | 0.64 | RAPGEF4 (0.43) | NFE2L2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4013495-B1 | ARYLSULFONAMIDE DERIVATIVES AS MGLUR4 NEGATIVE ALLOSTERIC MODULATORS | HOFFMANN LA ROCHE (CH) | 2023-09-27 | — | — | EP | disclosed |
| WO-2021028512-A1 | ARYLSULFONAMIDE DERIVATIVES AS MGLUR4 NEGATIVE ALLOSTERIC MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2021-02-18 | — | — | WO | disclosed |