Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2299249 | 0.69 | ALDH1A1 (0.35) | ALDH1A1MAPTKDM4ENPC1LMNA | |
| SCHEMBL21858847 | 0.68 | ALDH1A1 (0.48) | ALDH1A1MAPTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL15950989 | 0.67 | COMT (0.60) | ALDH1A1MAPTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL31148036 | 0.65 | ALDH1A1 (0.41) | ALDH1A1MAPTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL27002204 | 0.64 | ALDH1A1 (0.43) | ALDH1A1MAPTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL30060833 | 0.63 | CYP1A2 (0.46) | ALDH1A1MAPTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL16826278 | 0.62 | CYP3A4 (0.53) | ALDH1A1MAPTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL17369090 | 0.62 | CYP1A2 (0.53) | ALDH1A1MAPTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL29132897 | 0.62 | COMT (0.46) | ALDH1A1MAPTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL8121886 | 0.62 | ALDH1A1 (0.45) | ALDH1A1MAPTCOMTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592475-B2 | Inhibitors of Akt activity | GLAXOSMITHKLINE LLC (US) | 2013-11-26 | — | — | US | disclosed |
| US-20110196009-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION | 2011-08-11 | — | — | US | disclosed |
| US-20110196009-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION | 2011-08-11 | — | — | US | disclosed |
| US-20110196009-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION | 2011-08-11 | — | — | US | disclosed |
| WO-2010045309-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-04-22 | — | — | WO | disclosed |
| WO-2010045309-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110196009-A1 | INHIBITORS OF Akt ACTIVITY | AKT2, AKT1, AKT3 | ALDH1A1 3652/4885MAPT 4189/4885PIK3CD 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.