⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10644138 | 0.88 | BLM (0.40) | — | |
| SCHEMBL950791 | 0.86 | BLM (0.48) | — | |
| SCHEMBL292718 | 0.83 | CHRNB2 (0.43) | — | |
| SCHEMBL2305994 | 0.81 | — | — | |
| SCHEMBL16271579 | 0.81 | DPP4 (0.51) | — | |
| SCHEMBL23210724 | 0.80 | — | — | |
| SCHEMBL18228152 | 0.78 | — | — | |
| SCHEMBL1569788 | 0.78 | KDM4E (0.42) | — | |
| SCHEMBL1066805 | 0.78 | ALDH1A1 (0.41) | — | |
| SCHEMBL15529923 | 0.77 | DPP4 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148429-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES | SELVITA S.A. (PL) | 2018-05-31 | — | — | US | claimed |
| EP-3294729-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES | SELVITA S.A. (PL) | 2018-03-21 | — | — | EP | claimed |
| WO-2016180536-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES | SELVITA S.A. (PL) | 2016-11-17 | — | — | WO | claimed |
| US-20160200741-A1 | Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection | HOFFMANN-LA ROCHE INC. (US) | 2016-07-14 | — | — | US | claimed |
| WO-2016004272-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-01-07 | — | — | WO | claimed |
| US-9206191-B2 | Indazoles for the treatment and prophylaxis of respiratory syncytial virus infection | HOFFMANN-LA ROCHE INC. (US) | 2015-12-08 | — | — | US | claimed |
| US-20150158879-A1 | Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection | HOFFMANN-LA ROCHE INC. (US) | 2015-06-11 | — | — | US | claimed |
| EP-2872502-A1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2015-05-20 | — | — | EP | claimed |
| WO-2014009302-A1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2014-01-16 | — | — | WO | claimed |
| US-20120316150-A1 | AMIDE COMPOUNDS USEFUL IN THERAPY | PFIZER INC. | 2012-12-13 | — | — | US | claimed |
| US-8232269-B2 | Amide compounds useful in therapy | PFIZER INC. (US) | 2012-07-31 | — | — | US | claimed |
| EP-2350017-A1 | AMIDE COMPOUNDS USEFUL IN THERAPY | Pfizer Limited (GB) | 2011-08-03 | — | — | EP | claimed |
| US-20100249091-A1 | Amide Compounds Useful in Therapy | GIBSON KARL RICHARD | 2010-09-30 | — | — | US | claimed |
| WO-2010032200-A1 | AMIDE COMPOUNDS USEFUL IN THERAPY | PFIZER LIMITED (GB) | 2010-03-25 | — | — | WO | claimed |
| EP-0131374-B1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PENEM DERIVATIVES | PFIZER INC. (US) | 1988-11-23 | — | — | EP | claimed |
| US-4619783-A | BACTERICIDES | PFIZER INC. (US) | 1986-10-28 | — | — | US | claimed |
| EP-0131374-A1 | Process and intermediates for the preparation of penem derivatives | PFIZER INC. (US) | 1985-01-16 | — | — | EP | claimed |
| US-20180148429-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES | SELVITA S.A. (PL) | 2018-05-31 | — | — | US | disclosed |
| US-4619783-A | BACTERICIDES | PFIZER INC. (US) | 1986-10-28 | — | — | US | disclosed |
| EP-0131374-A1 | Process and intermediates for the preparation of penem derivatives | PFIZER INC. (US) | 1985-01-16 | — | — | EP | disclosed |