Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | AQP1 | P29972 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 2/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29481447 | 1.00 | CA2 (0.40) | CA2CA1KLKB1SLC6A4SLC6A2 | |
| SCHEMBL30052791 | 0.88 | CA2 (0.40) | CA2CA1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL24997327 | 0.88 | CA2 (0.40) | CA2CA1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2638179 | 0.77 | CASR (0.47) | CA2SLC6A4SLC6A2SLC6A3CASR | |
| SCHEMBL23920083 | 0.76 | AKR1B1 (0.39) | CA2CA1SLC6A4SLC6A2HRH4 | |
| SCHEMBL23920087 | 0.76 | AHR (0.35) | CA2CA1KLKB1HTR2CAHR | |
| SCHEMBL22955689 | 0.76 | AKR1B1 (0.39) | CA2CA1SLC6A4SLC6A2HRH4 | |
| SCHEMBL23920182 | 0.76 | AKR1B1 (0.39) | CA2CA1SLC6A4SLC6A2HRH4 | |
| SCHEMBL23013290 | 0.74 | ADAMTS5 (0.40) | KLKB1 | |
| SCHEMBL29481459 | 0.74 | ADAMTS5 (0.40) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017586-A1 | ENZYME INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2022-06-29 | — | — | EP | disclosed |
| CN-114269431-A | Enzyme inhibitors | 卡尔维斯塔制药有限公司 | 2022-04-01 | — | — | CN | disclosed |
| WO-2021032933-A1 | ENZYME INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-25 | — | — | WO | disclosed |
| WO-2021032933-A1 | ENZYME INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-25 | — | — | WO | disclosed |