SCHEMBL23014548

Cc1ccc(C(NCCCC[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)N[C@@H](CSC(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)N2CCC[C@H]2C(=O)O)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	PRCP	P42785	1/20	0.42

▸	MDM2	Q00987	2/20	0.40

▸	ACE	P12821	6/20	0.38

▸	ACE2	Q9BYF1	2/20	0.38

▸	TLR2	O60603	2/20	0.36

▸	PTPN1	P18031	1/20	0.36

▸	MDM4	O15151	1/20	0.36

▸	TP53	P04637	1/20	0.36

▸	LMNA	P02545	1/20	0.35

▸	FDFT1	P37268	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL23014549	1.00	PRCP (0.42)	PRCPMDM2ACEACE2TLR2
SCHEMBL24817625	0.88	PRCP (0.37)	PRCPMDM2ACETLR2PTPN1
SCHEMBL29757443	0.88	PRCP (0.37)	PRCPMDM2ACETLR2PTPN1
SCHEMBL24817624	0.88	PRCP (0.37)	PRCPMDM2ACETLR2PTPN1
SCHEMBL23030719	0.88	PRCP (0.37)	PRCPMDM2ACETLR2PTPN1
SCHEMBL23014552	0.87	MDM2 (0.48)	MDM2TLR2PTPN1MDM4TP53
SCHEMBL29757411	0.87	MDM2 (0.48)	MDM2TLR2PTPN1MDM4TP53
SCHEMBL23014551	0.87	MDM2 (0.48)	MDM2TLR2PTPN1MDM4TP53
SCHEMBL30962356	0.86	PRCP (0.46)	PRCPMDM2ACEACE2MDM4
SCHEMBL23014547	0.83	ACE (0.35)	ACEACE2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-4017866-A1	METHODS OF MAKING INCRETIN ANALOGS	Eli Lilly and Company (US)	2022-06-29	—	—	EP	disclosed
WO-2021034815-A1	METHODS OF MAKING INCRETIN ANALOGS	ELI LILLY AND COMPANY (US)	2021-02-25	—	—	WO	disclosed