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Sugi Predict / Compounds / SCHEMBL23014547

SCHEMBL23014547

SCHEMBL23014547

COC(=O)N(C1c2ccccc2-c2ccccc21)[C@@H](CCCCNC(c1ccccc1)(c1ccccc1)c1ccc(C)cc1)C(=O)N[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)O

nearest known ligand 0.35

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ ACE P12821 12/20 0.35
▸ LMNA P02545 1/20 0.34
▸ ACE2 Q9BYF1 5/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23014548 0.83 PRCP (0.42) ACELMNAACE2
SCHEMBL23014549 0.83 PRCP (0.42) ACELMNAACE2
SCHEMBL436025 0.77 KIF11 (0.34) LMNA
SCHEMBL436023 0.77 KIF11 (0.34) LMNA
SCHEMBL24817624 0.73 PRCP (0.37) ACE
SCHEMBL29757443 0.73 PRCP (0.37) ACE
SCHEMBL24817625 0.73 PRCP (0.37) ACE
SCHEMBL23030719 0.73 PRCP (0.37) ACE
SCHEMBL31639850 0.71 PDCD1 (0.42) ACE
SCHEMBL30962356 0.71 PRCP (0.46) ACELMNAACE2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4017866-A1 METHODS OF MAKING INCRETIN ANALOGS Eli Lilly and Company (US) 2022-06-29 — — EP disclosed
WO-2021034815-A1 METHODS OF MAKING INCRETIN ANALOGS ELI LILLY AND COMPANY (US) 2021-02-25 — — WO disclosed
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