Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.60 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.60 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.60 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.60 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.60 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.60 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16654040 | 0.86 | NPC1 (0.60) | NPC1RAB9AMAPKAPK2ALDH1A1GAA | |
| SCHEMBL23015669 | 0.83 | RAB9A (0.62) | NPC1RAB9ASMN1; SMN2TP53PRKAB2 | |
| SCHEMBL23015752 | 0.82 | RAB9A (0.67) | NPC1RAB9ASMN1; SMN2PRKAB2PRKAG1 | |
| SCHEMBL23015834 | 0.81 | PRKAB2 (0.59) | NPC1RAB9ASMN1; SMN2TP53PRKAB2 | |
| SCHEMBL20016542 | 0.81 | MEN1 (0.58) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL6174621 | 0.80 | RAB9A (0.73) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL21348760 | 0.80 | KMT2A (0.54) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL29899004 | 0.80 | MAPK8 (0.62) | NPC1RAB9ASMN1; SMN2PRKAB2PRKAG1 | |
| SCHEMBL23410523 | 0.80 | MAPK8 (0.62) | NPC1RAB9ASMN1; SMN2PRKAB2PRKAG1 | |
| SCHEMBL23446461 | 0.80 | MAPK8 (0.62) | NPC1RAB9ASMN1; SMN2PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10927106-B2 | Benzothiazole derivatives as DYRK1 inhibitors | PHARMASUM THERAPEUTICS AS (NO) | 2021-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927106-B2 | Benzothiazole derivatives as DYRK1 inhibitors | DYRK1A, DYRK1B, PDK2 | NPC1 2121/4885RAB9A 1200/4885SMN1; SMN2 2813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.