SCHEMBL2301604

SCHEMBL2301604

Cc1onc(-c2c(Cl)cccc2Cl)c1COc1c(F)cc(CCC(=O)O)cc1F

nearest known ligand 0.56

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 11/20 0.56
NR1H4 Q96RI1 8/20 0.54
FABP1 P07148 2/20 0.54
TDP1 Q9NUW8 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
PPARD Q03181 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2304166 0.86 FFAR4 (0.74) FFAR4PPARD
SCHEMBL2301669 0.85 FFAR4 (0.76) FFAR4
SCHEMBL2308463 0.83 FFAR4 (0.75) FFAR4
SCHEMBL2302512 0.81 FFAR4 (0.58) FFAR4
SCHEMBL2303184 0.80 FFAR4 (0.78) FFAR4
SCHEMBL2303025 0.74 FFAR4 (0.58) FFAR4
SCHEMBL2306966 0.73 FFAR4 (0.63) FFAR4
SCHEMBL2306113 0.73 NR1H4 (0.89) NR1H4FABP1PPARD
SCHEMBL1179449 0.73 NR1H4 (0.78) NR1H4PPARD
SCHEMBL3640481 0.72 NR1H4 (0.62) NR1H4FABP1PPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2690095-A1 Aryl gpr120 receptor agonists and uses thereof Camabay Therapeutics, Inc. (US) 2014-01-29 EP claimed
EP-2350016-A2 ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF Metabolex Inc. (US) 2011-08-03 EP claimed
US-20100216827-A1 ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF METABOLEX, INC. 2010-08-26 US claimed
WO-2010048207-A2 ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF METABOLEX, INC. (US) 2010-04-29 WO claimed
EP-2690095-A1 Aryl gpr120 receptor agonists and uses thereof Camabay Therapeutics, Inc. (US) 2014-01-29 EP disclosed
EP-2690095-A1 Aryl gpr120 receptor agonists and uses thereof Camabay Therapeutics, Inc. (US) 2014-01-29 EP disclosed
EP-2350016-A2 ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF Metabolex Inc. (US) 2011-08-03 EP disclosed
US-20100216827-A1 ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF METABOLEX, INC. 2010-08-26 US disclosed
US-20100216827-A1 ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF METABOLEX, INC. 2010-08-26 US disclosed
US-20100216827-A1 ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF METABOLEX, INC. 2010-08-26 US disclosed
WO-2010048207-A2 ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF METABOLEX, INC. (US) 2010-04-29 WO disclosed
WO-2010048207-A2 ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF METABOLEX, INC. (US) 2010-04-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100216827-A1 ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF GPR119, GPR52, GCGR FFAR4 24/4885NR1H4 59/4885FABP1 147/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.