Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | BAD | Q92934 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.33 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KCNK18 | Q7Z418 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29424782 | 0.88 | DRD1 (0.39) | DRD1BCL2L1BADTSHRCES1 | |
| SCHEMBL29924184 | 0.88 | DRD1 (0.39) | DRD1BCL2L1BADTSHRCES1 | |
| SCHEMBL665033 | 0.88 | DRD1 (0.39) | DRD1BCL2L1BADTSHRCES1 | |
| SCHEMBL22471754 | 0.86 | CES1 (0.35) | DRD1BCL2L1BADCES1TDP1 | |
| Iodide SCHEMBL9231386 | 0.86 | DRD1 (0.38) | DRD1BCL2L1BADTSHRCES1 | |
| Iodide SCHEMBL9231383 | 0.86 | DRD1 (0.38) | DRD1BCL2L1BADTSHRCES1 | |
| SCHEMBL9192628 | 0.86 | DRD1 (0.38) | DRD1BCL2L1BADTSHRCES1 | |
| SCHEMBL14356045 | 0.84 | DRD1 (0.39) | DRD1BCL2L1BADTSHRCES1 | |
| SCHEMBL2914738 | 0.83 | BCL2L1 (0.34) | DRD1BCL2L1BADTSHRKDM4E | |
| SCHEMBL30664383 | 0.83 | BCL2L1 (0.34) | DRD1BCL2L1BADTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111217848-B | Spiro-dihydrobenzothiole diphenol compound, synthesis method and application thereof | 中国科学院上海有机化学研究所 | 2021-11-02 | — | — | CN | claimed |
| CN-111484437-A | Method for introducing tertiary isopentenyl group to C3 position of indole | 中国科学院大连化学物理研究所 | 2020-08-04 | — | — | CN | claimed |
| CN-111484436-A | Method for introducing isopentenyl group to C3 position of indole | 中国科学院大连化学物理研究所 | 2020-08-04 | — | — | CN | claimed |
| CN-111217848-A | Spiro-dihydrobenzothiole diphenol compound, synthesis method and application thereof | 中国科学院上海有机化学研究所 | 2020-06-02 | — | — | CN | claimed |
| CN-111171068-A | Preparation method of silicon spiro-compound | 中国科学院上海有机化学研究所 | 2020-05-19 | — | — | CN | claimed |
| CN-113735669-B | Method for constructing alpha-acyllactam quaternary carbon chiral center compound by nickel-catalyzed asymmetric allyl alkylation and compound | 四川大学 | 2022-06-14 | — | — | CN | disclosed |
| CN-111484436-B | Method for introducing isopentene group into C3 position of indole | 中国科学院大连化学物理研究所 | 2022-06-07 | — | — | CN | disclosed |
| CN-111484437-B | Method for introducing tertiary isopentenyl group to C3 position of indole | 中国科学院大连化学物理研究所 | 2022-06-07 | — | — | CN | disclosed |
| CN-114423844-A | Photoresponsive coordination compound with photocontrol electron transport and conduction characteristics and manufacture of organic electronic device and organic resistance memory device with photoconversion performance | 香港大学 | 2022-04-29 | — | — | CN | disclosed |
| CN-111171068-B | Preparation method of silicon spiro-compound | 中国科学院上海有机化学研究所 | 2021-12-14 | — | — | CN | disclosed |
| CN-113735669-A | Method for constructing alpha-acyllactam quaternary carbon chiral center compound by nickel-catalyzed asymmetric allyl alkylation and compound | 四川大学 | 2021-12-03 | — | — | CN | disclosed |
| CN-113321669-A | Sulfimide metal salt, preparation method and application thereof | 中国科学院上海有机化学研究所 | 2021-08-31 | — | — | CN | disclosed |
| EP-2536733-A1 | TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION | Boehringer Ingelheim International GmbH (DE) | 2012-12-26 | — | — | EP | disclosed |
| WO-2012110599-A1 | TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-08-23 | — | — | WO | disclosed |
| WO-2011101424-A1 | TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-25 | — | — | WO | disclosed |
| US-7351849-B2 | Process for producing optically active β-amino acid derivatives | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2008-04-01 | — | — | US | disclosed |
| US-6613805-B2 | For therapy and prophylaxis of neurodegenerative diseases such as Alzheimer's disease, Down's syndrome, Parkinson's disease, Creutzfeldt-Jacob disease, amyotrophic sclerosis on lateral fasciculus, multiple sclerosis, and neurological disorders | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-02 | — | — | US | disclosed |
| US-20020032189-A1 | For therapy and prophylaxis of neurodegenerative diseases such as Alzheimer's disease, Down's syndrome, Parkinson's disease, Creutzfeldt-Jacob disease, amyotrophic sclerosis on lateral fasciculus, multiple sclerosis, and neurological disorders | THE UNIVERSITY OF TOKYO (JP) | 2002-03-14 | — | — | US | disclosed |
| EP-0855390-A1 | A process for producing optically active pyrrolidine derivatives | Takasago International Corporation (JP) | 1998-07-29 | — | — | EP | disclosed |
| EP-0839819-A1 | Method of preparing optically active diphosphine ligands | Takasago International Corporation (JP) | 1998-05-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032189-A1 | For therapy and prophylaxis of neurodegenerative diseases such as Alzheimer's disease, Down's syndrome, Parkinson's disease, Creutzfeldt-Jacob disease, amyotrophic sclerosis on lateral fasciculus, multiple sclerosis, and neurological disorders | PARK7, PSEN1, PRNP | DRD1 738/4885BCL2L1 327/4885BAD 3250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.