Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 4/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4453952 | 1.00 | MAOA (0.46) | MAOANOX1KDM1AADRA2AADRA2B | |
| SCHEMBL9457298 | 0.72 | KDM1A (0.38) | MAOAKDM1AADRA2AADRA2BADRA2C | |
| SCHEMBL10903996 | 0.72 | KDM1A (0.38) | MAOAKDM1AADRA2AADRA2BADRA2C | |
| SCHEMBL1451143 | 0.67 | MAOA (0.50) | MAOANOX1ADRA2AADRA2BADRA2C | |
| SCHEMBL851761 | 0.64 | MAOA (0.40) | MAOAADRA2CDRD3TP53DRD2 | |
| SCHEMBL851762 | 0.64 | MAOA (0.40) | MAOAADRA2CDRD3TP53DRD2 | |
| SCHEMBL231247 | 0.64 | MAOA (1.00) | MAOANOX1KDM1AADRA2AADRA2B | |
| SCHEMBL29377505 | 0.64 | MAOA (1.00) | MAOANOX1KDM1AADRA2AADRA2B | |
| SCHEMBL28983302 | 0.62 | MAOA (0.45) | MAOANOX1KDM1AADRA2AADRA2B | |
| SCHEMBL14865924 | 0.60 | MAOA (0.74) | MAOANOX1KDM1AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5081282-A | Bicyclo compounds, inhibitors of thromboxane activity | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1992-01-14 | — | — | US | claimed |
| US-5077309-A | Thromboxane a2 antagonist | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1991-12-31 | — | — | US | claimed |
| US-5055582-A | Process for preparing thromboxane A2 antagonists | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1991-10-08 | — | — | US | claimed |
| US-5028733-A | Prostaglandins | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1991-07-02 | — | — | US | claimed |
| US-5025034-A | Thromboxane inhibitors | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1991-06-18 | — | — | US | claimed |
| US-5006539-A | Thromborane inhibitor | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1991-04-09 | — | — | US | claimed |
| US-4992563-A | Benzopyran intermediates for use in manufacturing thromboxane A2 antagonists | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1991-02-12 | — | — | US | claimed |
| US-4945106-A | Prostaglandins | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1990-07-31 | — | — | US | claimed |
| EP-0231078-B1 | PROSTAGLANDINS | NAT RES DEV (GB) | 1990-04-25 | — | — | EP | claimed |
| EP-0082646-B1 | PROSTAGLANDINS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1989-11-15 | — | — | EP | claimed |
| US-4837234-A | Prostaglandins | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1989-06-06 | — | — | US | claimed |
| US-4628061-A | Prostaglandins | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1986-12-09 | — | — | US | claimed |
| US-4596823-A | Prostaglandins | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1986-06-24 | — | — | US | claimed |
| EP-0043292-B1 | PROSTAGLANDINS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1986-01-15 | — | — | EP | claimed |
| US-8877757-B2 | Pyrazine derivatives and use as PI3K inhibitors | MERCK SERONO SA (CH) | 2014-11-04 | — | — | US | disclosed |
| US-20110319410-A1 | PYRAZINE DERIVATIVES AND USE AS PI3K INHIBITORS | MERCK SERONO SA (CH) | 2011-12-29 | — | — | US | disclosed |
| US-20110312960-A1 | PYRAZINE DERIVATIVES AND USE AS PI3K INHIBITORS | MERCK SERONO SA (CH) | 2011-12-22 | — | — | US | disclosed |
| EP-0231078-B1 | PROSTAGLANDINS | NAT RES DEV (GB) | 1990-04-25 | — | — | EP | disclosed |
| EP-0082646-B1 | PROSTAGLANDINS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1989-11-15 | — | — | EP | disclosed |
| US-4594303-A | Containing charge generating and charge transfer material | FUJI PHOTO FILM CO., LTD. (JP) | 1986-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312960-A1 | PYRAZINE DERIVATIVES AND USE AS PI3K INHIBITORS | PIK3R5, PIK3CD, PIK3CA | MAOA 3651/4885NOX1 516/4885KDM1A 4376/4885 |
| US-20110319410-A1 | PYRAZINE DERIVATIVES AND USE AS PI3K INHIBITORS | PIK3R5, PIK3CD, PIK3CA | MAOA 3651/4885NOX1 516/4885KDM1A 4376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.