SCHEMBL851762

SCHEMBL851762

CN1[C]N(C)c2ccccc21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.40
GAA P10253 4/20 0.37
ALDH1A1 P00352 2/20 0.37
LMNA P02545 1/20 0.37
PAX8 Q06710 1/20 0.37
MCL1 Q07820 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
TTR P02766 1/20 0.36
CES1 P23141 1/20 0.36
GPR3 P46089 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ADRA2C P18825 1/20 0.33
KDM4E B2RXH2 2/20 0.32
MAPT P10636 1/20 0.32
HPGD P15428 1/20 0.32
MEN1 O00255 1/20 0.32
USP2 O75604 1/20 0.32
TP53 P04637 1/20 0.32
HTT P42858 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL851761 1.00 MAOA (0.40) MAOAGAAALDH1A1LMNAPAX8
SCHEMBL1274000 0.71 SMN1; SMN2 (0.41) ALDH1A1SMN1; SMN2KDM4EMAPTHTT
SCHEMBL482716 0.69 MAOA (0.60) MAOAGAAALDH1A1LMNAPAX8
SCHEMBL4571020 0.69 MAOA (0.60) MAOAGAAALDH1A1LMNAPAX8
SCHEMBL29390564 0.69 MAOA (0.60) MAOAGAAALDH1A1LMNAPAX8
SCHEMBL13636983 0.69
SCHEMBL17049638 0.69 MAOA (0.40) MAOAGAAALDH1A1LMNAPAX8
SCHEMBL5434365 0.68 P2RX4 (0.36) MAOAALDH1A1LMNASMN1; SMN2ADRA2C
SCHEMBL30705335 0.67 MAOA (0.43) MAOAGAAALDH1A1LMNAPAX8
SCHEMBL29151795 0.67 MAOA (0.43) MAOAGAAALDH1A1LMNAPAX8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4139281-B1 SULFUR EXTRUSION FROM DISULFIDES BY CARBENES UNIV HEIDELBERG (DE) 2024-05-08 EP claimed
US-20230151054-A1 SULFUR EXTRUSION FROM DISULFIDES BY CARBENES Universität Heidelberg (DE) 2023-05-18 US claimed
EP-3901135-A1 SULFUR EXTRUSION FROM DISULFIDES BY CARBENES Universität Heidelberg (DE) 2021-10-27 EP claimed
EP-3135681-B1 RUTHENIUM COMPLEX, METHOD FOR PRODUCING SAME, AND USE OF SAME TAKASAGO PERFUMERY CO LTD (JP) 2020-08-19 EP claimed
WO-2000030632-A1 ARYL AND HETEROARYL COMPOUNDS USEFUL AS FIBROBLAST GROWTH FACTOR ANTAGONISTS EISAI CO., LTD. (JP) 2000-06-02 WO claimed
US-12012426-B2 Tetradentate diaminodiphosphine ligand and transition metal complex, and method for manufacturing same and application for same TAKASAGO INTERNATIONAL CORPORATION (JP) 2024-06-18 US disclosed
CN-112654630-B Tetradentate diaminodiphosphine ligands, transition metal complexes, methods for their production and use thereof 高砂香料工业株式会社 2024-05-24 CN disclosed
EP-4139281-B1 SULFUR EXTRUSION FROM DISULFIDES BY CARBENES UNIV HEIDELBERG (DE) 2024-05-08 EP disclosed
US-20230219983-A1 TETRADENTATE DIAMINODIPHOSPHINE LIGAND AND TRANSITION METAL COMPLEX, AND METHOD FOR MANUFACTURING SAME AND APPLICATION FOR SAME TAKASAGO INTERNATIONAL CORPORATION (JP) 2023-07-13 US disclosed
US-20230151054-A1 SULFUR EXTRUSION FROM DISULFIDES BY CARBENES Universität Heidelberg (DE) 2023-05-18 US disclosed
US-11639362-B2 Tetradentate diaminodiphosphine ligand and transition metal complex, and method for manufacturing same and application for same TAKASAGO INTERNATIONAL CORPORATION (JP) 2023-05-02 US disclosed
EP-3901135-A1 SULFUR EXTRUSION FROM DISULFIDES BY CARBENES Universität Heidelberg (DE) 2021-10-27 EP disclosed
US-20090270552-A1 POLYMERIZABLE COMPOSITION AND MOLDED PRODUCT THEREOF SUGAWARA TOMOO 2009-10-29 US disclosed
US-7579404-B2 Polymerizable composition and molded product thereof ZEON CORPORATION (JP) 2009-08-25 US disclosed
EP-1652885-B1 POLYMERIZABLE COMPOSITION AND FORMED ARTICLE USING THE SAME ZEON CORP (JP) 2009-03-11 EP disclosed
US-7465773-B2 Polymerizable composition and formed article using the same ZEON CORPORATION (JP) 2008-12-16 US disclosed
US-20060293444-A1 Polymerizable composition and molded product thereof ZEON CORPORATION (JP) 2006-12-28 US disclosed
US-20060211809-A1 Polymerizable composition and formed article using the same ZEON CORPORATION (JP) 2006-09-21 US disclosed
EP-1655319-A1 POLYMERIZABLE COMPOSITION AND FORMED BODY THEREOF Zeon Corporation (JP) 2006-05-10 EP disclosed
EP-1652885-A1 POLYMERIZABLE COMPOSITION AND FORMED ARTICLE USING THE SAME Zeon Corporation (JP) 2006-05-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230219983-A1 TETRADENTATE DIAMINODIPHOSPHINE LIGAND AND TRANSITION METAL COMPLEX, AND METHOD FOR MANUFACTURING SAME AND APPLICATION FOR SAME ADH4, ADH5, PF4 MAOA 438/4885GAA 3778/4885ALDH1A1 219/4885
US-12012426-B2 Tetradentate diaminodiphosphine ligand and transition metal complex, and method for manufacturing same and application for same ADH4, ADH5, PF4 MAOA 438/4885GAA 3778/4885ALDH1A1 219/4885
US-11639362-B2 Tetradentate diaminodiphosphine ligand and transition metal complex, and method for manufacturing same and application for same ADH4, ADH5, PF4 MAOA 438/4885GAA 3778/4885ALDH1A1 219/4885
US-20230151054-A1 SULFUR EXTRUSION FROM DISULFIDES BY CARBENES TST, CBS, CTH MAOA 4429/4885GAA 4559/4885ALDH1A1 1786/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.