Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 2/20 | 0.30 |
| ▸ | PREP | P48147 | 1/20 | 0.30 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22999824 | 0.86 | LMNA (0.34) | LMNAMAPTCYP2C9ALOX15CYP2C19 | |
| SCHEMBL22999615 | 0.84 | TP53 (0.47) | GPR119TP53DDB1CRBNMAPT | |
| SCHEMBL22999969 | 0.81 | DDB1 (0.40) | TP53DDB1CRBNMAPT | |
| SCHEMBL23021084 | 0.75 | GPR119 (0.38) | GPR119TP53CHRM2CHRM1CHRM3 | |
| SCHEMBL22206970 | 0.73 | MAPT (0.44) | TP53LMNAMAPTCYP2C9ALOX15 | |
| SCHEMBL22206969 | 0.73 | MAPT (0.44) | TP53LMNAMAPTCYP2C9ALOX15 | |
| SCHEMBL22216336 | 0.73 | MAPT (0.44) | TP53LMNAMAPTCYP2C9ALOX15 | |
| SCHEMBL27834792 | 0.72 | CHRM2 (0.38) | GPR119CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL3061518 | 0.71 | GPR119 (0.39) | GPR119TP53CHRM2CHRM1CHRM3 | |
| SCHEMBL23907169 | 0.71 | MAPT (0.53) | TP53ATMLMNAMAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021032323-A1 | FUSED PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROTIC DISEASES | GALAPAGOS NV (BE) | 2021-02-25 | — | — | WO | disclosed |
| EP-3782997-A1 | FUSED PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROTIC DISEASES | Galapagos N.V. (BE) | 2021-02-24 | — | — | EP | disclosed |