Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2300932 | 0.89 | SCN9A (0.42) | SCN9AEPHX2PTGS1PTGS2 | |
| SCHEMBL2301156 | 0.84 | SCN9A (0.42) | SCN9AEPHX2KDRBRAFFFAR4 | |
| SCHEMBL2302295 | 0.83 | HTR1A (0.47) | SCN9A | |
| SCHEMBL3125948 | 0.80 | PTGS1 (0.41) | PTGS1PTGS2FFAR4 | |
| SCHEMBL2298969 | 0.80 | EPHX2 (0.45) | EPHX2 | |
| SCHEMBL26933404 | 0.78 | SCN9A (0.36) | SCN9AEPHX2KDRBRAFKCNN4 | |
| SCHEMBL26933399 | 0.78 | SCN9A (0.36) | SCN9AEPHX2KDRBRAFKCNN4 | |
| SCHEMBL2296998 | 0.78 | MGLL (0.44) | SCN9AEPHX2 | |
| Hydrochloric Acid SCHEMBL30636264 | 0.77 | SCN9A (0.35) | SCN9AEPHX2KDRBRAFKCNN4 | |
| SCHEMBL3123082 | 0.76 | SLC6A2 (0.42) | SCN9APTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |