Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA3 | P07451 | 2/20 | 0.34 |
| ▸ | CA4 | P22748 | 2/20 | 0.34 |
| ▸ | CA6 | P23280 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | CBFB | Q13951 | 2/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3436381 | 0.79 | KDM4E (0.49) | HSD17B10CA2CA12CA3CA4 | |
| SCHEMBL904586 | 0.76 | SLC5A2 (0.46) | HSD17B10APPRPS6KA5HDAC6 | |
| SCHEMBL15971092 | 0.75 | SLC5A2 (0.47) | HSD17B10CA2CA12CA3CA4 | |
| SCHEMBL15687224 | 0.72 | HDAC6 (0.45) | ESR2HDAC6 | |
| SCHEMBL19763377 | 0.71 | ESR2 (0.47) | HSD17B10ESR2 | |
| SCHEMBL15687365 | 0.69 | ALDH1A1 (0.36) | HSD17B10CBFBHDAC6 | |
| SCHEMBL21575908 | 0.68 | NPC1 (0.40) | HSD17B10TYRPDE10A | |
| SCHEMBL16152984 | 0.68 | CYP1A2 (0.41) | HSD17B10 | |
| SCHEMBL1206769 | 0.66 | CA2 (0.54) | HSD17B10CA2CA12CA3CA4 | |
| SCHEMBL29749150 | 0.66 | CA2 (0.54) | HSD17B10CA2CA12CA3CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021032148-A1 | AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-02-25 | — | — | WO | disclosed |