Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18854449 | 0.79 | CYP2D6 (0.44) | CYP2D6CYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL29335336 | 0.78 | KIF11 (0.47) | CYP2D6CYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL8750570 | 0.77 | KDM4E (0.40) | CYP2D6CYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL11229694 | 0.76 | HTR1D (0.44) | CYP2D6CYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL255111 | 0.76 | KDM4E (0.42) | CYP2D6CYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL21531653 | 0.76 | CYP2D6 (0.42) | CYP2D6CYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL10211670 | 0.76 | KLF10 (0.50) | CYP2D6CYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL11223586 | 0.76 | PON1 (0.46) | CYP2D6CYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL21449928 | 0.74 | CYP2D6 (0.41) | CYP2D6CYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL12724796 | 0.74 | CYP2C19 (0.67) | CYP2D6CYP1A2CYP2C19ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210053989-A1 | PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | SHANGHAI BLUERAY BIOPHARMA CO., LTD. (CN) | 2021-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210053989-A1 | PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | PTPN11, PPM1F, PTPRF | CYP2D6 2083/4885CYP1A2 4226/4885CYP2C19 3558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.