Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.41 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL658248 | 0.99 | PRKCZ (0.45) | PRKCZGAAKEAP1HSD17B10RAB9A | |
| SCHEMBL2302345 | 0.90 | PRKCZ (0.57) | PRKCZGAAKEAP1HSD17B10RAB9A | |
| SCHEMBL658905 | 0.85 | F9 (0.43) | PRKCZGAAHSD17B10RAB9ALMNA | |
| SCHEMBL5794188 | 0.83 | SCN10A (0.45) | PRKCZHSD17B10RAB9AKMT2ACYP1A2 | |
| SCHEMBL659483 | 0.79 | PRKCZ (0.72) | PRKCZHSD17B10RAB9AGABBR2GABBR1 | |
| SCHEMBL2356966 | 0.78 | PRKCZ (0.43) | PRKCZHSD17B10RAB9ALMNATSHR | |
| Hydrochloric Acid SCHEMBL657199 | 0.78 | PRKCZ (0.71) | PRKCZHSD17B10RAB9AGABBR2GABBR1 | |
| Hydrochloric Acid SCHEMBL657578 | 0.77 | PRKCZ (0.42) | PRKCZHSD17B10RAB9ACYP2C9LMNA | |
| SCHEMBL658906 | 0.75 | SIRT2 (0.47) | PRKCZHSD17B10RAB9ACYP1A2F9 | |
| SCHEMBL5109491 | 0.75 | SCN10A (0.57) | GAAHSD17B10RAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | claimed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | claimed |
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |