Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.45 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2300182 | 0.85 | PIK3CD (0.60) | MAPTKMT2AMEN1PIK3CGPIK3CD | |
| SCHEMBL2304596 | 0.83 | PIK3CG (0.60) | MAPTKMT2AMEN1KDM4EHTT | |
| SCHEMBL1936834 | 0.78 | PPARG (0.61) | MAPTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL2300703 | 0.78 | PIK3CD (0.60) | MAPTKMT2AMEN1KDM4EHTT | |
| SCHEMBL4347409 | 0.77 | PIK3CD (0.58) | MAPTKMT2AMEN1KDM4EHTT | |
| SCHEMBL2300765 | 0.75 | PIK3CG (0.60) | MAPTKMT2AMEN1KDM4EHTT | |
| SCHEMBL189862 | 0.74 | MAPT (0.69) | MAPTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL188337 | 0.72 | MEN1 (0.66) | MAPTKMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL4484711 | 0.71 | PIK3CG (0.57) | MAPTKMT2AMEN1KDM4ELMNA | |
| SCHEMBL4338570 | 0.70 | PIK3CG (0.58) | MAPTKMT2AMEN1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351745-A1 | Pyrazine derivatives and use as PI3K inhibitors | Merck Serono S.A. (CH) | 2011-08-03 | — | — | EP | disclosed |