⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11882765 | 0.94 | — | — | |
| SCHEMBL9319092 | 0.81 | TSHR (0.30) | — | |
| SCHEMBL28270141 | 0.72 | — | — | |
| SCHEMBL11778510 | 0.71 | — | — | |
| SCHEMBL7585 | 0.69 | — | — | |
| SCHEMBL180621 | 0.69 | TP53 (0.30) | — | |
| SCHEMBL2302735 | 0.69 | — | — | |
| SCHEMBL27471897 | 0.67 | — | — | |
| SCHEMBL6233086 | 0.67 | — | — | |
| SCHEMBL28495934 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10905782-B2 | Compositions for enhancing transport of molecules into cells | SAREPTA THERAPEUTICS, INC. (US) | 2021-02-02 | — | — | US | disclosed |
| US-10300149-B2 | Compositions for enhancing transport of molecules into cells | SAREPTA THERAPEUTICS, INC. (US) | 2019-05-28 | — | — | US | disclosed |
| US-20170368203-A1 | Compositions For Enhancing Transport Of Molecules Into Cells | SAREPTA THERAPEUTICS, INC. | 2017-12-28 | — | — | US | disclosed |
| US-9572899-B2 | Compositions for enhancing transport of molecules into cells | AVI BIOPHARMA, INC. (US) | 2017-02-21 | — | — | US | disclosed |
| EP-2351844-B1 | COMPOSITIONS FOR ENHANCING TRANSPORT AND ANTISENSE EFFICACY OF NUCLEIC ACID ANALOG INTO CELLS | SAREPTA THERAPEUTICS INC (US) | 2014-06-11 | — | — | EP | disclosed |
| EP-2351844-A1 | Compositions for enhancing transport and antisense efficacy of nucleic acid analog into cells | AVI BioPharma, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-1629105-B1 | COMPOSITIONS FOR ENHANCING TRANSPORT AND ANTISENSE EFFICACY OF NUCLEIC ACID ANALOG INTO CELLS | AVI BIOPHARMA INC (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20090082547-A1 | COMPOSITIONS FOR ENHANCING TRANSPORT OF MOLECULES INTO CELLS | SAREPTA THERAPEUTICS, INC. | 2009-03-26 | — | — | US | disclosed |
| US-7468418-B2 | peptide nucleic acid conjugate of a nucleic acid analog covalently linked to a peptide transporter moiety; enhance antisense activity; drug delivery; conjugate is a morpholino-base with phosphorodiamidate linkages with a peptide such as Arg9Phe2 (arginine9phenylalanine2) | AVI BIOPHARMA., INC. (US) | 2008-12-23 | — | — | US | disclosed |
| EP-1629105-A2 | COMPOSITIONS FOR ENHANCING TRANSPORT AND ANTISENSE EFFICACY OF NUCLEIC ACID ANALOG INTO CELLS | Avi Biopharma, Inc. (US) | 2006-03-01 | — | — | EP | disclosed |
| US-5378841-A | Alpha-morpholino ribonucleoside derivatives and polymers thereof | ANTIVIRALS INC. (US) | 1995-01-03 | — | — | US | disclosed |
| WO-1994012517-A1 | SEQUENCE-SPECIFIC BINDING POLYMERS FOR DUPLEX NUCLEIC ACIDS | ANTIVIRALS INC. (US) | 1994-06-09 | — | — | WO | disclosed |
| EP-0592511-A1 | SEQUENCE-SPECIFIC BINDING POLYMERS FOR DUPLEX NUCLEIC ACIDS. | ANTIVIRALS INC (US) | 1994-04-20 | — | — | EP | disclosed |
| US-5235033-A | ALPHA-MORPHOLINO RIBONUCLEOSIDE DERIVATIVES AND POLYMERS THEREOF | ANTI-GENE DEVELOPMENT GROUP (US) | 1993-08-10 | — | — | US | disclosed |
| US-5185444-A | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages | ANTI-GENE DEVEOPMENT GROUP (US) | 1993-02-09 | — | — | US | disclosed |
| WO-1993000352-A1 | SEQUENCE-SPECIFIC BINDING POLYMERS FOR DUPLEX NUCLEIC ACIDS | ANTIVIRALS INC. (US) | 1993-01-07 | — | — | WO | disclosed |
| EP-0506830-A4 | UNCHARGED MORPHOLINO-BASED POLYMERS HAVING PHOSPHOROUS-CONTAINING CHIRAL INTERSUBUNIT LINKAGES | — | 1993-01-07 | — | — | EP | disclosed |
| US-5166315-A | Polynucleotides for genetic engineering | ANTI-GENE DEVELOPMENT GROUP (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0506830-A1 | UNCHARGED MORPHOLINO-BASED POLYMERS HAVING PHOSPHOROUS-CONTAINING CHIRAL INTERSUBUNIT LINKAGES | ANTIVIRALS INC. (US) | 1992-10-07 | — | — | EP | disclosed |
| WO-1991009033-A1 | UNCHARGED MORPHOLINO-BASED POLYMERS HAVING PHOSPHOROUS-CONTAINING CHIRAL INTERSUBUNIT LINKAGES | ANTI-GENE DEVELOPMENT GROUP (US) | 1991-06-27 | — | — | WO | disclosed |