Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TNKS | O95271 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23030158 | 0.79 | KDM4E (0.36) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL24858352 | 0.76 | KDM4E (0.35) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL24858349 | 0.71 | KDM4E (0.35) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL11821659 | 0.67 | ALDH1A1 (0.45) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL10309385 | 0.65 | PDE10A (0.45) | HSD17B10PDE10A | |
| SCHEMBL6118459 | 0.65 | EGLN2 (0.50) | KDM4ETSHRALDH1A1MAPK1HTT | |
| SCHEMBL19477683 | 0.65 | KDM4E (0.34) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL3209050 | 0.65 | CYP11B2 (0.37) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL17252308 | 0.64 | KDM4E (0.37) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL23030303 | 0.62 | KDM4E (0.38) | KDM4EHPGDHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4019521-A1 | AZAHETEROARYL COMPOUND AND APPLICATION THEREOF | Blueray Therapeutics (Shanghai) Co., Ltd (CN) | 2022-06-29 | — | — | EP | disclosed |
| WO-2021032004-A9 | AZAHETEROARYL COMPOUND AND APPLICATION THEREOF | 上海青煜医药科技有限公司 | 2021-03-25 | — | — | WO | disclosed |
| WO-2021032004-A1 | AZAHETEROARYL COMPOUND AND APPLICATION THEREOF | 上海青煜医药科技有限公司 | 2021-02-25 | — | — | WO | disclosed |