Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 15/20 | 0.39 |
| ▸ | ITK | Q08881 | 15/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24005850 | 0.77 | PRMT5 (0.42) | BTKITKPRMT5WDR77JAK2 | |
| SCHEMBL91445 | 0.77 | AXL (0.41) | BTKITKPRMT5WDR77JAK2 | |
| Hydrochloric Acid SCHEMBL17442826 | 0.73 | BTK (0.41) | BTKITKPRMT5WDR77JAK2 | |
| SCHEMBL7443703 | 0.73 | PRMT5 (0.48) | BTKITKPRMT5WDR77JAK2 | |
| SCHEMBL31150914 | 0.73 | BTK (0.40) | BTKITKPRMT5WDR77JAK2 | |
| SCHEMBL19754798 | 0.73 | BTK (0.38) | BTKITKPRMT5WDR77JAK2 | |
| SCHEMBL18371565 | 0.73 | BTK (0.42) | BTKITKPRMT5WDR77JAK2 | |
| SCHEMBL25261133 | 0.73 | BTK (0.40) | BTKITKPRMT5WDR77JAK2 | |
| SCHEMBL17787159 | 0.73 | BTK (0.40) | BTKITKPRMT5WDR77JAK2 | |
| SCHEMBL29481417 | 0.73 | PRMT5 (0.48) | BTKITKPRMT5WDR77JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021032933-A1 | ENZYME INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-25 | — | — | WO | disclosed |