Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 7/20 | 0.40 |
| ▸ | ITK | Q08881 | 7/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20033884 | 0.77 | BTK (0.39) | PRMT5WDR77BTKITKNTRK1 | |
| SCHEMBL1564760 | 0.77 | ITK (0.54) | PRMT5WDR77BTKITKNTRK1 | |
| SCHEMBL91445 | 0.77 | AXL (0.41) | PRMT5WDR77BTKITKJAK2 | |
| SCHEMBL23030509 | 0.77 | BTK (0.39) | PRMT5WDR77BTKITKNTRK1 | |
| SCHEMBL10269012 | 0.77 | MET (0.43) | PRMT5WDR77BTKITKKIT | |
| SCHEMBL25971496 | 0.77 | BRD4 (0.47) | KITNTRK1GSK3BMAP3K11CLK1 | |
| SCHEMBL7443703 | 0.77 | PRMT5 (0.48) | PRMT5WDR77BTKITKKLKB1 | |
| SCHEMBL29481417 | 0.77 | PRMT5 (0.48) | PRMT5WDR77BTKITKKLKB1 | |
| SCHEMBL16186620 | 0.76 | KIT (0.72) | BTKITKKITNTRK1GSK3B | |
| Hydrochloric Acid SCHEMBL7213801 | 0.75 | PRMT5 (0.47) | PRMT5WDR77BTKITKKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021223736-A1 | COMPOUNDS AS BCL-2 INHIBITORS | FOCHON PHARMACEUTICALS, LTD. (CN) | 2021-11-11 | — | — | WO | disclosed |