SCHEMBL23037445

SCHEMBL23037445

COC(=O)c1ccc2c(c1)NC(=O)/C2=C(/Nc1ccc(N(C)C(=O)CN(C)C)cc1)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SENP1 Q9P0U3 2/20 0.43
AAK1 Q2M2I8 1/20 0.41
KMT2A Q03164 4/20 0.37
MEN1 O00255 3/20 0.37
CTDSP1 Q9GZU7 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
BACE1 P56817 2/20 0.37
CASP1 P29466 1/20 0.36
ALDH1A1 P00352 4/20 0.36
RAB9A P51151 3/20 0.36
THRB P10828 2/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
TP53 P04637 1/20 0.36
POLB P06746 1/20 0.36
BLM P54132 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
NPC1 O15118 2/20 0.35
PTPN1 P18031 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL437153 1.00 SENP1 (0.43) SENP1AAK1KMT2AMEN1CTDSP1
SCHEMBL1116389 1.00 SENP1 (0.43) SENP1AAK1KMT2AMEN1CTDSP1
SCHEMBL31093996 1.00 SENP1 (0.43) SENP1AAK1KMT2AMEN1CTDSP1
SCHEMBL3151609 0.93 SENP1 (0.46) SENP1KMT2AMEN1RXFP1ALDH1A1
SCHEMBL3151615 0.93 SENP1 (0.46) SENP1KMT2AMEN1RXFP1ALDH1A1
SCHEMBL23252132 0.93 SENP1 (0.43) SENP1AAK1KMT2AMEN1CTDSP1
SCHEMBL2567391 0.93 SENP1 (0.40) SENP1AAK1KMT2AMEN1CTDSP1
SCHEMBL480850 0.93 SENP1 (0.40) SENP1AAK1KMT2AMEN1CTDSP1
SCHEMBL480314 0.92 SENP1 (0.41) SENP1AAK1KMT2AMEN1CTDSP1
SCHEMBL479618 0.92 SENP1 (0.41) SENP1AAK1KMT2AMEN1CTDSP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3784213-A1 INHALABLE LIPOSOMAL SUSTAINED RELEASE COMPOSITION FOR USE IN TREATING PULMONARY DISEASES TLC Biopharmaceuticals, Inc. (US) 2021-03-03 EP disclosed