SCHEMBL437153

SCHEMBL437153

COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN(C)C)cc1)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SENP1 Q9P0U3 2/20 0.43
AAK1 Q2M2I8 1/20 0.41
KMT2A Q03164 4/20 0.37
MEN1 O00255 3/20 0.37
CTDSP1 Q9GZU7 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
BACE1 P56817 2/20 0.37
CASP1 P29466 1/20 0.36
ALDH1A1 P00352 4/20 0.36
RAB9A P51151 3/20 0.36
THRB P10828 2/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
TP53 P04637 1/20 0.36
POLB P06746 1/20 0.36
BLM P54132 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
NPC1 O15118 2/20 0.35
PTPN1 P18031 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23037445 1.00 SENP1 (0.43) SENP1AAK1KMT2AMEN1CTDSP1
SCHEMBL1116389 1.00 SENP1 (0.43) SENP1AAK1KMT2AMEN1CTDSP1
SCHEMBL31093996 1.00 SENP1 (0.43) SENP1AAK1KMT2AMEN1CTDSP1
SCHEMBL3151609 0.93 SENP1 (0.46) SENP1KMT2AMEN1RXFP1ALDH1A1
SCHEMBL3151615 0.93 SENP1 (0.46) SENP1KMT2AMEN1RXFP1ALDH1A1
SCHEMBL23252132 0.93 SENP1 (0.43) SENP1AAK1KMT2AMEN1CTDSP1
SCHEMBL2567391 0.93 SENP1 (0.40) SENP1AAK1KMT2AMEN1CTDSP1
SCHEMBL480850 0.93 SENP1 (0.40) SENP1AAK1KMT2AMEN1CTDSP1
SCHEMBL480314 0.92 SENP1 (0.41) SENP1AAK1KMT2AMEN1CTDSP1
SCHEMBL479618 0.92 SENP1 (0.41) SENP1AAK1KMT2AMEN1CTDSP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12533313-B2 Inhalable liposomal sustained release composition for use in treating pulmonary diseases INSPIRMED CORP. (TW) 2026-01-27 US claimed
US-20230088661-A1 INHALABLE LIPOSOMAL SUSTAINED RELEASE COMPOSITION FOR USE IN TREATING PULMONARY DISEASES INSPIRMED CORP (TW) 2023-03-23 US claimed
EP-3643309-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES Boehringer Ingelheim International GmbH (DE) 2020-04-29 EP claimed
US-20160136133-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES BOEHRINGER INGELHEIM INT (DE) 2016-05-19 US claimed
EP-2384751-B1 Medicaments for the treatment or prevention of fibrotic diseases BOEHRINGER INGELHEIM INT (DE) 2015-09-16 EP claimed
EP-2878297-A1 Medicaments for the treatment or prevention of fibrotic diseases Boehringer Ingelheim International GmbH (DE) 2015-06-03 EP claimed
EP-2826480-A1 Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis Boehringer Ingelheim International GmbH (DE) 2015-01-21 EP claimed
US-20140296217-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-10-02 US claimed
EP-2409705-A1 Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-01-25 EP claimed
EP-2384751-A1 Medicaments for the treatment or prevention of fibrotic diseases BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-11-09 EP claimed
WO-2007057397-A1 TREATMENT OF CANCER BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-05-24 WO claimed
US-20060142373-A1 Medicaments for the Treatment or Prevention of Fibrotic Diseases BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-06-29 US claimed
WO-2006067165-A2 INDOLIDONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-06-29 WO claimed
EP-1530466-A2 USE OF LCK INHIBITOR FOR TREATMENT OF IMMUNOLOGIC DISEASES Boehringer Ingelheim Pharma KG (DE) 2005-05-18 EP claimed
US-20050043233-A1 Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2005-02-24 US claimed
US-20040204458-A1 Use of Lck inhibitors for treatment of immunologic diseases BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2004-10-14 US claimed
US-6762180-B1 Substituted indolines which inhibit receptor tyrosine kinases BOEHRINGER INGELHEIM PHARMA KG (DE) 2004-07-13 US claimed
WO-2004017948-A2 USE OF LCK INHIBITOR FOR TREATMENT OF IMMUNOLOGIC DISEASES BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2004-03-04 WO claimed
EP-1224170-A1 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT Boehringer Ingelheim Pharma KG (DE) 2002-07-24 EP claimed
WO-2001027081-A1 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT BOEHRINGER INGELHEIM PHARMA KG (DE) 2001-04-19 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12533313-B2 Inhalable liposomal sustained release composition for use in treating pulmonary diseases ADRM1, ALK, AGK SENP1 1475/4885AAK1 57/4885KMT2A 2715/4885
US-20060142373-A1 Medicaments for the Treatment or Prevention of Fibrotic Diseases MMP1, COL1A1, FOXM1 SENP1 1815/4885AAK1 3831/4885KMT2A 4592/4885
US-20160136133-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES MMP1, COL1A1, FOXM1 SENP1 1815/4885AAK1 3831/4885KMT2A 4592/4885
US-20140296217-A1 MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES MMP1, COL1A1, FOXM1 SENP1 1815/4885AAK1 3831/4885KMT2A 4592/4885
US-20050043233-A1 Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis BAX, BCL2, CXCL12 SENP1 1101/4885AAK1 3958/4885KMT2A 4366/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.