Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 14/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23041664 | 1.00 | APLNR (0.39) | APLNRRIPK1SMPD1FAAHMDM2 | |
| SCHEMBL23041672 | 0.85 | ALPL (0.41) | RIPK1 | |
| SCHEMBL23041670 | 0.85 | ALPL (0.41) | RIPK1 | |
| SCHEMBL23042216 | 0.72 | CDK2 (0.40) | RIPK1 | |
| SCHEMBL23042217 | 0.72 | CDK2 (0.40) | RIPK1 | |
| SCHEMBL23041442 | 0.70 | PHGDH (0.35) | RIPK1 | |
| SCHEMBL23041445 | 0.70 | PHGDH (0.35) | RIPK1 | |
| SCHEMBL28722010 | 0.68 | HDAC3 (0.39) | RIPK1MDM2 | |
| SCHEMBL28722012 | 0.68 | HDAC3 (0.39) | RIPK1MDM2 | |
| SCHEMBL29452602 | 0.68 | HDAC3 (0.39) | RIPK1MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4021572-A1 | SUBSTITUTED 1,3-PHENYL HETEROARYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | Novartis AG (CH) | 2022-07-06 | — | — | EP | disclosed |
| CN-114341132-A | Substituted 1, 3-phenylheteroaryl derivatives and their use in the treatment of diseases | 诺华股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| WO-2021038426-A1 | SUBSTITUTED 1,3-PHENYL HETEROARYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-03-04 | — | — | WO | disclosed |