SCHEMBL2304228

SCHEMBL2304228

COC(=O)C1=CCN2C=CC=CC2=C1

nearest known ligand 0.30

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.30
CHRM2 P08172 1/20 0.30
CHRM4 P08173 1/20 0.30
CHRM5 P08912 1/20 0.30
THRB P10828 1/20 0.30
CHRM1 P11229 1/20 0.30
CHRM3 P20309 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10776088 0.84 TSHR (0.33)
SCHEMBL27751140 0.83
SCHEMBL2301142 0.81
Methane SCHEMBL2304232 0.80
Hydrochloric Acid SCHEMBL7615191 0.80
SCHEMBL18264399 0.80
SCHEMBL27740707 0.80
SCHEMBL3971398 0.80
SCHEMBL2299291 0.79
Hydrochloric Acid SCHEMBL7406597 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2536408-A1 EFFLUX PUMP INHIBITORS Wockhardt Research Centre (IN) 2012-12-26 EP claimed
WO-2011101710-A1 EFFLUX PUMP INHIBITORS WOCKHARDT RESEARCH CENTRE (IN) 2011-08-25 WO claimed
EP-2536408-A1 EFFLUX PUMP INHIBITORS Wockhardt Research Centre (IN) 2012-12-26 EP disclosed
WO-2011101710-A1 EFFLUX PUMP INHIBITORS WOCKHARDT RESEARCH CENTRE (IN) 2011-08-25 WO disclosed
CN-100372845-C Polycyclic compounds as potent alpha2-adrenoceptor antagonists ORION CORP (FI) 2008-03-05 CN disclosed
CN-1646528-A Polycyclic compounds as potent alpha2-adrenoceptor antagonists ORION CORP (FI) 2005-07-27 CN disclosed