SCHEMBL2304247

SCHEMBL2304247

O=C(O)c1c(Cl)cncc1OC(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALPL P05186 6/20 0.40
KMO O15229 2/20 0.40
GRIA1 P42261 1/20 0.38
CACNG8 Q8WXS5 1/20 0.38
EGLN1 Q9GZT9 1/20 0.37
AKR1C2 P52895 1/20 0.35
AKR1C1 Q04828 1/20 0.35
DHODH Q02127 1/20 0.34
CSNK2A2 P19784 1/20 0.34
CSNK2B P67870 1/20 0.34
ANO1 Q5XXA6 1/20 0.34
HCAR2 Q8TDS4 1/20 0.33
KDM4A O75164 1/20 0.33
KDM5A P29375 1/20 0.33
HDAC3 O15379 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC10 Q969S8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5201967 0.77 KDM4E (0.46)
SCHEMBL111872 0.75 HCAR2 (0.46) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL21826582 0.74 ASPH (0.39) KMOEGLN1HCAR2HDAC3HDAC4
SCHEMBL31125552 0.74 ASPH (0.39) KMOEGLN1HCAR2HDAC3HDAC4
Hydrochloric Acid SCHEMBL5204506 0.73 HCAR2 (0.45) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL5760445 0.73 HCAR2 (0.45) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL20118699 0.73 GRIA1 (0.44) ALPLKMOGRIA1CACNG8
Formaldehyde SCHEMBL28038712 0.72 HCAR2 (0.43) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL18189413 0.72 GRIA1 (0.38) ALPLGRIA1CACNG8
SCHEMBL6257319 0.71 ITGB1 (0.40) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2350008-A1 METHOD FOR THE PREPARATION OF FUNCTIONALIZED TRIHALOMETHOXY SUBSTITUTED PYRIDINES Bayer CropScience AG (DE) 2011-08-03 EP disclosed
WO-2010040461-A1 METHOD FOR THE PREPARATION OF FUNCTIONALIZED TRIHALOMETHOXY SUBSTITUTED PYRIDINES BAYER CROPSCIENCE AG (DE) 2010-04-15 WO disclosed