Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 7/20 | 0.44 |
| ▸ | FUCA1 | P04066 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GLB1 | P16278 | 1/20 | 0.44 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2304538 | 1.00 | GBA1 (0.44) | GBA1FUCA1GLAGAAGLB1 | |
| SCHEMBL2304542 | 1.00 | GBA1 (0.44) | GBA1FUCA1GLAGAAGLB1 | |
| SCHEMBL27644253 | 0.83 | GBA1 (0.44) | GBA1FUCA1GLAGAAGLB1 | |
| SCHEMBL1749165 | 0.83 | GBA1 (0.44) | GBA1FUCA1GLAGAAGLB1 | |
| SCHEMBL1749166 | 0.83 | GBA1 (0.44) | GBA1FUCA1GLAGAAGLB1 | |
| SCHEMBL1749164 | 0.83 | GBA1 (0.44) | GBA1FUCA1GLAGAAGLB1 | |
| SCHEMBL4594633 | 0.79 | CTSD (0.33) | — | |
| SCHEMBL1842034 | 0.76 | CHRNB2 (0.32) | — | |
| SCHEMBL1842036 | 0.76 | CHRNB2 (0.32) | — | |
| SCHEMBL1842039 | 0.76 | CHRNB2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415386-B2 | Azolopyrrolone melanin concentrating hormone receptor-1 antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-09 | — | — | US | disclosed |
| US-20110195934-A1 | AZOLOPYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2011-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195934-A1 | AZOLOPYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS | MC1R, MCHR1, MCHR2 | GBA1 3908/4885FUCA1 3371/4885GLA 2017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.