Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 6/20 | 0.45 |
| ▸ | CA9 | Q16790 | 6/20 | 0.45 |
| ▸ | CA12 | O43570 | 5/20 | 0.45 |
| ▸ | CA1 | P00915 | 5/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17231312 | 1.00 | LMNA (0.60) | LMNAKMT2APOLBALDH1A1CYP3A4 | |
| SCHEMBL19767509 | 1.00 | LMNA (0.60) | LMNAKMT2APOLBALDH1A1CYP3A4 | |
| SCHEMBL15344529 | 1.00 | LMNA (0.60) | LMNAKMT2APOLBALDH1A1CYP3A4 | |
| SCHEMBL15344523 | 1.00 | LMNA (0.60) | LMNAKMT2APOLBALDH1A1CYP3A4 | |
| SCHEMBL24219925 | 1.00 | LMNA (0.60) | LMNAKMT2APOLBALDH1A1CYP3A4 | |
| SCHEMBL15333945 | 1.00 | LMNA (0.60) | LMNAKMT2APOLBALDH1A1CYP3A4 | |
| SCHEMBL18710677 | 1.00 | LMNA (0.60) | LMNAKMT2APOLBALDH1A1CYP3A4 | |
| SCHEMBL16882358 | 1.00 | LMNA (0.60) | LMNAKMT2APOLBALDH1A1CYP3A4 | |
| SCHEMBL22511639 | 0.91 | LMNA (0.59) | LMNAKMT2APOLBALDH1A1CYP3A4 | |
| SCHEMBL18710675 | 0.90 | LMNA (0.50) | LMNAKMT2APOLBALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210308162-A1 | NOVEL TLR4 INHIBITORS FOR THE TREATMENT OF HUMAN INFECTIOUS AND INFLAMMATORY DISORDERS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-10-07 | — | — | US | disclosed |
| US-10933077-B2 | TLR4 inhibitors for the treatment of human infectious and inflammatory disorders | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2021-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210308162-A1 | NOVEL TLR4 INHIBITORS FOR THE TREATMENT OF HUMAN INFECTIOUS AND INFLAMMATORY DISORDERS | TLR4, TLR3, TLR1 | LMNA 3101/4885KMT2A 4485/4885POLB 4103/4885 |
| US-10933077-B2 | TLR4 inhibitors for the treatment of human infectious and inflammatory disorders | TLR4, TLR3, TLR1 | LMNA 2824/4885KMT2A 4503/4885POLB 4187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.