Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 8/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683646 | 0.90 | RET (0.40) | BRAFFLT3RETNTRK1NTRK3 | |
| SCHEMBL19683648 | 0.88 | LCK (0.45) | BRAFFLT3RETNTRK1 | |
| SCHEMBL19683697 | 0.84 | RET (0.44) | BRAFFLT3RETNTRK1NTRK3 | |
| SCHEMBL23047310 | 0.83 | RET (0.41) | BRAFFLT3RETNTRK1NTRK3 | |
| SCHEMBL19683630 | 0.82 | RAF1 (0.47) | BRAFFLT3RETNTRK1NTRK3 | |
| SCHEMBL19683716 | 0.81 | BRAF (0.52) | BRAFFLT3RETNTRK1NTRK3 | |
| SCHEMBL23047347 | 0.80 | RAF1 (0.48) | BRAFFLT3RET | |
| SCHEMBL20878934 | 0.80 | PRMT1 (0.37) | BRAF | |
| SCHEMBL20878925 | 0.79 | RET (0.50) | BRAFFLT3RETNTRK1NTRK3 | |
| SCHEMBL19683650 | 0.79 | RET (0.38) | BRAFFLT3RETNTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466952-B1 | 1-(4-(4-AMINO-3-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL)-PHENYL)-UREA DERIVATIVES AS FLT3 KINASE INHIBITORS FOR TREATING CANCER | PRECEDO PHARMACEUTICALS CO LTD (CN) | 2021-03-03 | — | — | EP | disclosed |