Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15120373 | 0.80 | RIPK1 (0.42) | IRAK4RIPK1MAP4K4SCN5AMKNK1 | |
| SCHEMBL20814388 | 0.78 | POLB (0.58) | IRAK4TDP1LMNA | |
| SCHEMBL16368638 | 0.76 | IRAK4 (0.44) | IRAK4RIPK1SCN5AMKNK1DRD2 | |
| SCHEMBL23055240 | 0.75 | TDP1 (0.34) | IRAK4TDP1MAP4K4ALDH1A1LMNA | |
| SCHEMBL24783502 | 0.74 | TDP1 (0.41) | IRAK4TDP1MAP4K4ALDH1A1LMNA | |
| SCHEMBL15686694 | 0.73 | SCN5A (0.40) | IRAK4RIPK1TDP1SCN5AALDH1A1 | |
| SCHEMBL25124503 | 0.71 | MAP4K4 (0.46) | TDP1MAP4K4LMNATSHRRECQL | |
| SCHEMBL25475739 | 0.71 | SCN5A (0.36) | RIPK1SCN5ADRD2DRD1DRD4 | |
| SCHEMBL2179468 | 0.70 | SCN5A (0.38) | RIPK1SCN5ADRD2DRD1DRD4 | |
| SCHEMBL12489666 | 0.70 | UGT2B7 (0.39) | IRAK4RIPK1SCN5ADRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021149767-A1 | HETEROCYCLIC DERIVATIVE | 大日本住友製薬株式会社 | 2021-07-29 | — | — | WO | disclosed |
| WO-2021039961-A1 | RING-FUSED PYRAZOLE DERIVATIVE | 大日本住友製薬株式会社 | 2021-03-04 | — | — | WO | disclosed |