SCHEMBL23055345

SCHEMBL23055345

O=C(O)Cn1ncc2ncc(Cl)nc21

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KMO O15229 1/20 0.46
GRIN2B Q13224 19/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30329260 0.86 GRIN2B (0.45) GRIN2B
SCHEMBL22772849 0.82 GRIN2B (0.61) GRIN2B
SCHEMBL24783517 0.80 GRIN2B (0.46) GRIN2B
SCHEMBL23055344 0.79 KDM4E (0.43) GRIN2B
SCHEMBL25227443 0.79 KMO (0.51) KMOGRIN2B
SCHEMBL25205678 0.79 KMO (0.51) KMOGRIN2B
SCHEMBL25227445 0.79 KMO (0.51) KMOGRIN2B
SCHEMBL25098948 0.77 ALDH1A1 (0.39) GRIN2B
SCHEMBL29489066 0.77 ALDH1A1 (0.39) GRIN2B
SCHEMBL23639069 0.76 KMO (0.57) KMO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230109839-A1 THERAPEUTIC AGENT FOR TAUOPATHIES Sumitomo Pharma Co., Ltd. (JP) 2023-04-13 US disclosed
EP-4104861-A1 THERAPEUTIC AGENT FOR TAUOPATHIES Sumitomo Pharma Co., Ltd. (JP) 2022-12-21 EP disclosed
WO-2021141041-A1 THERAPEUTIC AGENT FOR TAUOPATHIES 大日本住友製薬株式会社 2021-07-15 WO disclosed
WO-2021039961-A1 RING-FUSED PYRAZOLE DERIVATIVE 大日本住友製薬株式会社 2021-03-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230109839-A1 THERAPEUTIC AGENT FOR TAUOPATHIES MAPT, PSEN1, PSEN2 KMO 4398/4885GRIN2B 441/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.