Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | EIF2AK3 | Q9NZJ5 | 9/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 3/20 | 0.43 |
| ▸ | AXL | P30530 | 3/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29746667 | 1.00 | FLT3 (0.44) | FLT3EIF2AK3EGFRCDK1SRC | |
| SCHEMBL23043903 | 0.87 | FLT3 (0.50) | FLT3EIF2AK3EGFRCDK1SRC | |
| SCHEMBL29684025 | 0.86 | FLT3 (0.55) | FLT3EIF2AK3EGFRCDK1SRC | |
| SCHEMBL23043916 | 0.86 | FLT3 (0.55) | FLT3EIF2AK3EGFRCDK1SRC | |
| SCHEMBL29746670 | 0.85 | MET (0.49) | FLT3EIF2AK3EGFRCDK1SRC | |
| SCHEMBL23043850 | 0.85 | MET (0.49) | FLT3EIF2AK3EGFRCDK1SRC | |
| SCHEMBL29746539 | 0.83 | EIF2AK3 (0.51) | FLT3EIF2AK3EGFRCDK1SRC | |
| SCHEMBL23044049 | 0.83 | EIF2AK3 (0.51) | FLT3EIF2AK3EGFRCDK1SRC | |
| SCHEMBL23043868 | 0.83 | EIF2S1 (0.55) | FLT3EIF2AK3EGFRCDK1SRC | |
| SCHEMBL30060949 | 0.83 | EIF2S1 (0.55) | FLT3EIF2AK3EGFRCDK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114710956-A | PERK-INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | 希伯塞尔股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| WO-2021041975-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | HIBERCELL, INC. (US) | 2021-03-04 | — | — | WO | disclosed |