Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.55 |
| ▸ | AURKA | O14965 | 8/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.52 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.52 |
| ▸ | EIF2S1 | P05198 | 1/20 | 0.48 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 10/20 | 0.48 |
| ▸ | PLK4 | O00444 | 8/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 8/20 | 0.48 |
| ▸ | LCK | P06239 | 8/20 | 0.48 |
| ▸ | FLT4 | P35916 | 8/20 | 0.48 |
| ▸ | BLK | P51451 | 8/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 8/20 | 0.48 |
| ▸ | CSNK1G2 | P78368 | 8/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 8/20 | 0.48 |
| ▸ | STK3 | Q13188 | 8/20 | 0.48 |
| ▸ | HIPK4 | Q8NE63 | 8/20 | 0.48 |
| ▸ | SLK | Q9H2G2 | 8/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29684025 | 1.00 | FLT3 (0.55) | FLT3AURKAAURKBIKBKEEIF2S1 | |
| SCHEMBL30060901 | 0.93 | FLT3 (0.56) | FLT3AURKAAURKBIKBKEEIF2AK3 | |
| SCHEMBL23043903 | 0.91 | FLT3 (0.50) | FLT3AURKAAURKBIKBKEEIF2AK3 | |
| SCHEMBL23043850 | 0.89 | MET (0.49) | FLT3EIF2AK3AXLRETCDK1 | |
| SCHEMBL29746670 | 0.89 | MET (0.49) | FLT3EIF2AK3AXLRETCDK1 | |
| SCHEMBL23044049 | 0.86 | EIF2AK3 (0.51) | FLT3EIF2S1EIF2AK3AXLNTRK1 | |
| SCHEMBL29746539 | 0.86 | EIF2AK3 (0.51) | FLT3EIF2S1EIF2AK3AXLNTRK1 | |
| SCHEMBL29746667 | 0.86 | FLT3 (0.44) | FLT3EIF2AK3AXLRETCDK1 | |
| SCHEMBL23057572 | 0.86 | FLT3 (0.44) | FLT3EIF2AK3AXLRETCDK1 | |
| SCHEMBL23043897 | 0.85 | EIF2AK3 (0.53) | FLT3EIF2S1EIF2AK3AXLKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220356186-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | HIBERCELL, INC. | 2022-11-10 | — | — | US | claimed |
| EP-4021908-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | Hibercell, Inc. (US) | 2022-07-06 | — | — | EP | claimed |
| CN-114710956-A | PERK-INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | 希伯塞尔股份有限公司 | 2022-07-05 | — | — | CN | claimed |
| WO-2021231788-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS TO TREAT VIRAL INFECTIONS | HIBERCELL, INC. (US) | 2021-11-18 | — | — | WO | claimed |
| WO-2021041975-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | HIBERCELL, INC. (US) | 2021-03-04 | — | — | WO | claimed |
| US-20220356186-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | HIBERCELL, INC. | 2022-11-10 | — | — | US | disclosed |
| EP-4021908-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | Hibercell, Inc. (US) | 2022-07-06 | — | — | EP | disclosed |
| CN-114710956-A | PERK-INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | 希伯塞尔股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| WO-2021231788-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS TO TREAT VIRAL INFECTIONS | HIBERCELL, INC. (US) | 2021-11-18 | — | — | WO | disclosed |
| WO-2021041975-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | HIBERCELL, INC. (US) | 2021-03-04 | — | — | WO | disclosed |
| WO-2021041975-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | HIBERCELL, INC. (US) | 2021-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220356186-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | EEF2K, ATF4, MAPKAPK2 | FLT3 1250/4885AURKA 3121/4885AURKB 1999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.