Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 9/20 | 0.52 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.41 |
| ▸ | IDH1 | O75874 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | GPR3 | P46089 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23058771 | 0.80 | MC4R (0.39) | HDAC6 | |
| SCHEMBL23058487 | 0.79 | PDE2A (0.47) | PDE2AHDAC6 | |
| SCHEMBL12883103 | 0.75 | PDE2A (0.63) | PDE2AGPR139IDH1GPR3 | |
| SCHEMBL23059051 | 0.74 | PDE2A (0.48) | PDE2A | |
| SCHEMBL18290665 | 0.72 | PDE2A (0.60) | PDE2AGPR139IDH1GPR3 | |
| SCHEMBL16043293 | 0.72 | PDE2A (0.60) | PDE2AGPR139GPR3 | |
| SCHEMBL30557811 | 0.72 | PDE2A (0.60) | PDE2AGPR139GPR3 | |
| SCHEMBL17769060 | 0.72 | PDE2A (0.60) | PDE2AGPR139GPR3 | |
| SCHEMBL23058728 | 0.71 | PDE2A (0.44) | PDE2ANR1H2NR1H3 | |
| SCHEMBL23058734 | 0.71 | PDE2A (0.44) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021041588-A1 | SUBSTITUTED PYRIDOPYRIMIDINONYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-03-04 | — | — | WO | disclosed |