Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTO1 | P78417 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23044925 | 0.88 | ALDH1A1 (0.46) | ALDH1A1POLBSMN1; SMN2GAATHRB | |
| SCHEMBL23044920 | 0.87 | GSTO1 (0.44) | GSTO1LMNAALDH1A1JAK3SMN1; SMN2 | |
| SCHEMBL21430983 | 0.86 | ALDH1A1 (0.50) | GSTO1TP53LMNAALDH1A1JAK3 | |
| SCHEMBL23044908 | 0.85 | GSTO1 (0.43) | GSTO1TP53LMNAALDH1A1JAK3 | |
| SCHEMBL29214307 | 0.84 | GSTO1 (0.45) | GSTO1LMNAALDH1A1JAK3SMN1; SMN2 | |
| SCHEMBL21430738 | 0.81 | GSTO1 (0.45) | GSTO1LMNAALDH1A1POLBJAK3 | |
| Hydrochloric Acid SCHEMBL3962928 | 0.81 | POLB (0.48) | TP53LMNAALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL29214310 | 0.81 | GSTO1 (0.43) | GSTO1TP53LMNAALDH1A1POLB | |
| SCHEMBL21332113 | 0.81 | TP53 (0.46) | TP53LMNAALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL21430909 | 0.80 | HPGD (0.47) | GSTO1LMNAALDH1A1JAK3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4023639-A1 | PYRAZOLE DERIVATIVE FOR FGFR INHIBITOR AND PREPARATION METHOD THEREFOR | Etern Biopharma (Shanghai) Co., Ltd. (CN) | 2022-07-06 | — | — | EP | disclosed |
| WO-2021037219-A1 | PYRAZOLE DERIVATIVE FOR FGFR INHIBITOR AND PREPARATION METHOD THEREFOR | 上海奕拓医药科技有限责任公司 | 2021-03-04 | — | — | WO | disclosed |